SURFACE-MODIFIED MATERIALS, SUCH AS CONTACT LENSES, METHODS AND KITS FOR THEIR PREPARATION, AND USES THEREOF
First Claim
1. A method of modifying a contact lens with a carrier moiety capable of associating with an agent, said method comprising contacting, in one or more steps, one or more of (a) said contact lens comprising a first ligand attached thereto and (b) said carrier moiety comprising a second ligand attached thereto, with (c) an adapter molecule capable of concurrent binding to said first and second ligands, under conditions permitting binding of said adapter molecule to said first and second ligands, wherein said first and second ligands may be the same or different.
2 Assignments
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Accused Products
Abstract
Modified contact lenses and surfaces, methods for their preparation, and corresponding kits are disclosed. Also disclosed are uses of the contact lenses, such as for the administration of an agent to the eye.
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Citations
54 Claims
- 1. A method of modifying a contact lens with a carrier moiety capable of associating with an agent, said method comprising contacting, in one or more steps, one or more of (a) said contact lens comprising a first ligand attached thereto and (b) said carrier moiety comprising a second ligand attached thereto, with (c) an adapter molecule capable of concurrent binding to said first and second ligands, under conditions permitting binding of said adapter molecule to said first and second ligands, wherein said first and second ligands may be the same or different.
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18. A kit for modifying a contact lens comprising:
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(a) a contact lens comprising a first ligand attached thereto;
(b) a carrier moiety comprising a second ligand attached thereto; and
(c) an adapter molecule capable of binding said first and second ligands. - View Dependent Claims (20, 21, 22, 23)
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- 24. A contact lens comprising carrier moieties bound thereto, wherein a first ligand is attached to said contact lens, a second ligand is attached to said carrier moieties, and said first and second ligands are concurrently bound to an adapter molecule, said first and second ligands may be the same or may be different and said adapter molecule is capable of binding said first and second ligands concurrently.
- 43. A method for modifying a contact lens which comprises a functional group attached thereto, comprising incubating said contact lens in the presence of a coupling agent capable of reacting with said functional group to activate said functional group.
- 46. A method of modifying a surface comprising contacting said surface with a solution of a polymer in cloud point conditions under conditions permitting the reaction of a first functional group with a second functional group, wherein said surface comprises said first functional group attached thereto, said polymer comprises said second functional group attached thereto and said first and second functional groups can react with each other to form a covalent link.
- 50. A kit for modifying a surface comprising first functional groups attached thereto, said kit comprising a solution of a polymer in cloud point conditions and instructions for incubating said surface in said polymer solution, wherein said polymer comprises second functional groups attached thereto and said first and second functional groups can react with each other to form a covalent link.
- 52. An article of manufacture comprising a surface onto which a polymer has been covalently linked by incubating said article of manufacture or surface thereof in a solution of the polymer in cloud point conditions under conditions permitting the reaction of first and second functional groups, wherein said surface comprises said first functional groups attached thereto, said polymer comprises said second functional groups attached thereto and said first and second functional groups can react with each other to form a covalent link.
Specification