MICROPLATE WITH FEWER PERIPHERAL ARTIFACTS

• US 20080095673A1
• Filed: 10/21/2007
• Published: 04/24/2008
• Est. Priority Date: 10/20/2006
• Status: Abandoned Application

• Current Assignee: Lin Xu
• Original Assignee: Lin Xu
• Inventors: Xu, Lin
• Application Number:
  US11/875,906
• Publication Number:
  US 20080095673A1
• Time in Patent Office: Days
• US Class Current: 422/400
• CPC Class Codes: B01L 2200/14 Process control and prevention of errors
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 2300/18 Means for temperature control
• CPC Class Codes: B01L 3/50851 specially adapted for heating or cooling samples laboratory heating apparatus B01L7/00; incubators C12M

Abstract

The current invention relates to an improved microplate. The microplate is characterized by modified quadrilateral edges, which bring less artificially induced inaccuracies in peripheral wells, especially in corner wells. Preferably, the microplate possesses a bottom that is elongated to cover the non-experimental slots. The microplate might further comprise sham wells.

Claims

1. A microplate, comprising:

(a) a plurality of micro-wells (3);

(b) said micro-wells further consisting of a plurality of peripheral wells (9) surrounding a plurality of internal wells (10), so that said peripheral wells are of surrounding disparity compared to said internal wells;

(c) the improvement comprising means of structure adaptation on peripheral areas for compensating said surrounding disparity of said peripheral wells;

whereby said peripheral wells can be deprived of peripheral artifacts associated with said surrounding disparity.

2. The microplate of claim 1, comprising:

(a) four side-walls (5) supporting said plurality of micro-wells

(b) an elongation (13) surrounding said plurality of micro-wells;

(d) the improvement wherein said elongation (13) enabling a closure of the space between said side-walls and said plurality of micro-wells from underneath;

whereby convective heat exchange within said non-experimental slots is prevented.

3. The microplate of claim 2, further comprising air-through notches (16) at said side-walls (5), whereby allowing air convection beneath said bottom.

4. The microplate of claim 2 wherein the shape of said microwell is chosen from a group consisting of flat bottom shape, round bottom shape, V bottom shape, conical bottom shape, pyramid bottom shape, and mixtures thereof.

5. The microplate of claim 2 wherein the thickness of side-wall (5) is increased to to two to four times of a predetermined wall thickness of said internal well;

whereby heat transmission via side-walls is retarded

6. The microplate of claim 2 wherein a releasable layer is attached to said side walls (5).

7. A microplate of claim 6 wherein said layer is chosen from a group consisting of heatproof materials, soundproof materials, lightproof materials, post-casting treatment, and the like.

8. An alternative of the microplate of claim 2 wherein said elongation is replaced by a releasable undercover.

9. The microplate of claim 1, further comprising a plurality of sham wells (19) surrounding peripheral wells (9);

so that said sham wells substantially compensate surrounding disparity of said peripheral wells (9).

10. The microplate of claim 9 wherein said sham wells (19) are designed for holding sham samples, so that said sham samples further compensate surrounding disparity of said peripheral wells (9).

11. The microplate of claim 9 wherein size of said sham well (19) is chosen from a group consisting of a bigger size, a similar size, or a smaller size compared to the size of an internal well (10).

12. The microplate of claim 9 wherein said sham wells (19) are equal in size to internal wells (10), so that substantially compensate said surrounding disparity of said peripheral wells.

13. An alternative to the microplate of claim 9, where in a plurality of sham wells (19) are said peripheral wells (9).

14. The microplate of claim 1 wherein said peripheral wells further comprising peripheral well-walls;

characterized in that the thickness of said peripheral well-walls (12) is increased to two to four times of a predetermined thickness.

15. The microplate of claim 1 wherein said peripheral wells further comprising peripheral well-walls;

characterized in that a releasable layer is attached to said peripheral well walls (12).

16. The microplate of claim 15 wherein said layer is chosen from a group consisting of heatproof materials, soundproof materials, lightproof materials, post-casting treatment, and the like.

17. A microplate comprising a plurality of microwells;

the improvement wherein said microplate is co-packaging with an information sheet notifying users of the artifacts of peripheral wells and preventive ways thereof.

18. The microplate of claim 17 wherein said microplate is further co-packaged with a sticky layer for peripheral well walls and/or side-walls;

and the material of said layer is chosen from a group consisting of heatproof materials, soundproof materials, lightproof materials, post-casting treatment, and the like.