Methods of treating stroke
First Claim
1. A method for treating a subject suffering from a stroke comprising delivering to the subject through a vascular access device, a pharmaceutical composition comprising a therapeutically effective amount of a fibrinolytic metalloproteinase.
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Abstract
A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of α2-macroglobulin in the circulating blood. A method is also provided for the treatment of a blood clot in, around or attached to an indwelling vascular access device. A method for restoring patency and function of an indwelling vascular access device is also provided.
35 Citations
12 Claims
- 1. A method for treating a subject suffering from a stroke comprising delivering to the subject through a vascular access device, a pharmaceutical composition comprising a therapeutically effective amount of a fibrinolytic metalloproteinase.
- 10. A method for treating a human suffering from a stroke, said method comprising delivering to the human through a catheter device a therapeutically effective amount of Novel Acting Thrombolytic (NAT) comprising the amino acid sequence of SEQ ID NO:
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