Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis
First Claim
1. A method of reducing or inhibiting proliferation or metastasis of cells of a prostate tumor characterized by elevated Hedgehog (Hh) pathway activity as compared with a normal cell, comprising contacting the cells with at least one Hh pathway antagonist, thereby reducing or inhibiting proliferation of the cells of the prostate tumor.
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Abstract
Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in prostate tumors, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a prostate cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a prostate tumor to treatment with an Hh pathway antagonist.
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Citations
56 Claims
- 1. A method of reducing or inhibiting proliferation or metastasis of cells of a prostate tumor characterized by elevated Hedgehog (Hh) pathway activity as compared with a normal cell, comprising contacting the cells with at least one Hh pathway antagonist, thereby reducing or inhibiting proliferation of the cells of the prostate tumor.
- 12. A method of ameliorating a prostate tumor in a subject, comprising administering to the subject an Hh pathway antagonist, whereby the Hh pathway antagonist contacts cells of the tumor in the subject, thereby ameliorating the prostate tumor in the subject.
- 22. A method of identifying a prostate tumor of a subject amenable to treatment with a Hedgehog (Hh) pathway antagonist, comprising detecting elevated Hh pathway activity in a sample of cells from the subject as compared to Hh pathway activity in corresponding normal cells, thereby identifying a prostate tumor of a subject amenable to treatment with an Hh pathway antagonist.
- 48. A method of identifying an agent useful for treating a prostate tumor or metastatsis wherein the tumor cells have elevated Hedgehog (Hh) pathway activity, comprising contacting a sample of cells of a prostate tumor with at least one test agent, wherein a decrease in Hh pathway activity in the presence of the test agent as compared to Hh pathway activity in the absence of the test agent identifies the agent as useful for treating the prostate tumor.
Specification