PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE
First Claim
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1. A method of preventing or treating a disease associated with amyloid deposits of Aβ
- in the brain of a patient, comprising administering to the patient an effective dosage of a polypeptide comprising an N-terminal segment of Aβ
, the segment beginning at residue 1-3 of Aβ and
ending at residues 7-11 of Aβ
.
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Abstract
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
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Citations
33 Claims
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1. A method of preventing or treating a disease associated with amyloid deposits of Aβ
- in the brain of a patient, comprising administering to the patient an effective dosage of a polypeptide comprising an N-terminal segment of Aβ
, the segment beginning at residue 1-3 of Aβ and
ending at residues 7-11 of Aβ
. - View Dependent Claims (33)
- in the brain of a patient, comprising administering to the patient an effective dosage of a polypeptide comprising an N-terminal segment of Aβ
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2-29. -29. (canceled)
Specification