SYSTEM AND METHOD FOR DISPLAYING A PHARMACOKINETIC AND PHARMACODYNAMIC DRUG MODEL

• US 20080097167A1
• Filed: 01/04/2007
• Published: 04/24/2008
• Est. Priority Date: 10/18/2006
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Yudkovitch, Laurence, Mitton, Michael P., Coffeng, Rene J., Makin, Ronald P.
• Granted Patent: US 8,326,545 B2
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61K 31/08 acyclic, e.g. paraformaldehyde
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16H 70/40 relating to drugs, e.g. their side effects or intended usage

Abstract

A system and method for displaying a pharmacokinetics/pharmacodynamics drug model for a patient is provided. A monitor is arranged to detect a quantity of anesthetic agent provided to a patient by an anesthesia machine. A display is provided for displaying real-time pharmacokinetics data associated with the quantity of anesthetic agent provided to the patient. Safety control means are provided to initiate the display of real-time pharmacokinetics data for the anesthetic agent only when a predetermined threshold value for the anesthetic agent is detected by the monitor. Alternately, control means are adapted to terminate display of real-time pharmacokinetics data for the anesthetic agent when a predetermined threshold value for the anesthetic agent is detected by the monitor.

Claims

1. A system for displaying a PK/PD drug model for a patient, the system comprising:

a treatment device for providing an anesthetic agent to the patient;

a monitor for detecting a quantity of the anesthetic agent provided to the patient;

a display for displaying real-time PK/PD data associated with the anesthetic agent; and

safety control means adapted to initiate the display of real-time PK/PD data for the anesthetic agent only when a predetermined threshold value associated with the anesthetic agent is detected by the monitor.

2. The system of claim 1, wherein the monitor is arranged to detect the fraction of anesthetic agent expired by the patient and the fraction of anesthetic agent inspired by the patient, and wherein the safety control means only initiates the display of PK/PD data for the anesthetic agent when the fraction of expired anesthetic agent is greater than about 0.3% and when the fraction of expired anesthetic agent is not equal to the fraction of inspired anesthetic agent.

3. The system of claim 2, wherein the system continues to display pharmacokinetics data when the fraction of expired anesthetic agent becomes less than about 0.3%.

4. The system of claim 1, wherein the monitor is arranged to detect the fraction of anesthetic agent expired by the patient and the fraction of anesthetic agent inspired by the patient, wherein the anesthetic agent is N₂O, and wherein the safety control means only initiates display of PK/PD data for the N₂O when the fraction of expired N₂O is greater than about 3% and the fraction of expired N₂O is not equal to the fraction of inspired N₂O.

5. The system of claim 4, wherein the system continues to display PK/PD data for the N₂O when the fraction of expired N₂O becomes less than about 3%.

6. The system of claim 1 wherein the threshold value is equal to the value at which the inhaled agent has an effect on the PK/PD drug model.

7. The system of claim 1, wherein the safety control means is adapted to provide an error message on the display if the threshold value is detected.

8. The system of claim 6, wherein the anesthetic agent is at least one of Isoflurane, Sevoflurane, Enflurane, and Halothane, and wherein the threshold value is at least one of the following:

when the fraction of inspired anesthetic agent is greater than about 0.3%,

when the effect site concentration of the anesthetic agent is greater than about 0.3%, or

when the end tidal anesthetic agent is greater than about 0.3%.

9. The system of claim 6, wherein the anesthetic agent is Desflurane and the threshold value is at least one of the following:

when the fraction of Desflurane is greater than about 0.3%,

when the effect site concentration of Desflurane is greater than about 0.3% times the MAC_age, or

when the end tidal Desflurane is greater than about 0.3%.

10. The system of claim 6, wherein the anesthetic agent is N₂O and the threshold value is at least one of the following:

when the fraction of N₂O is greater than about 0.3%,

when the effect site concentration of N₂O is greater than about 0.3% times the minimum effect site concentration of the N₂O, or

when the end tidal N₂O is greater than about 0.3%.

11. The system of claim 6, wherein the anesthetic agent is at least one of Isoflurane, Sevoflurane, Enflurane, and Halothane and the threshold value is when the effect site concentration of the anesthetic agent is greater than about 0.3%*Age MAC awake.

12. The system of claim 6, wherein the anesthetic agent is N₂O and the threshold value is when the effect site concentration of N₂O is greater than about 0.1*Age MAC awake.

13. The system of claim 7, wherein the error message indicates that drug interactions are unknown.

14. A system for displaying a PK/PD drug model for a patient, the system comprising:

a treatment device for providing an anesthetic agent to the patient;

a display for displaying real-time PK/PD data associated the anesthetic agent provided to the patient; and

safety control means adapted to terminate display of real-time PK/PD data for the anesthetic agent when a predetermined threshold value associated with the anesthetic agent is computed by the system.

15. The system of claim of 14, wherein the system terminates display of real-time PK/PD data when the effect site concentration for the anesthetic agent remains below a predetermined level for a predetermined time period.

16. The system of claim 14, wherein the system terminates display of real-time PK/PD data when one or more monitored anesthetic agents have a positive fraction inspired value or a positive end tidal value and wherein all anesthetic agents remain below the threshold value for a predetermined time period.

17. The system of claim 14, wherein the system terminates display of real-time PK/PD data when a monitored respiration rate and heart rate are invalid or when the monitor is disconnected.

18. The system of claim 14, wherein the system displays an end case message when the threshold value is detected.

19. A method for displaying a PK/PD drug model for a patient, the method comprising the steps of:

detecting a quantity of the anesthetic agent provided to the patient; and

displaying real-time PK/PD data associated with the anesthetic agent only when a predetermined threshold value associated the anesthetic agent is detected by the monitor.

20. A system for displaying a PK/PD drug model for a patient, the system comprising:

a treatment device for providing anesthetic agent to the patient;

a display for displaying real-time PK/PD data associated with the anesthetic agent provided to the patient; and

safety control means adapted to display an error message if it detects a communication problem with the connected device.

21. The system of claim 20, wherein the system terminates display of real-time PK/PD data when communication with the connected device is severed.

22. The system of claim 20, wherein after communication is restored with the connected device, the system removes the error message.

23. The system of claim 22, wherein the system queries the connected device for data missed during the communication error.