SAMPLING DEVICE

• US 20080097241A1
• Filed: 10/18/2007
• Published: 04/24/2008
• Est. Priority Date: 10/18/2006
• Status: Abandoned Application

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Scherer, Axel, MALTEZOS, George
• Application Number:
  US11/874,830
• Publication Number:
  US 20080097241A1
• Time in Patent Office: Days
• US Class Current: 600/576
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150351 Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel caps for bottles or containers in general B65D41/00
• CPC Class Codes: A61B 5/150412 Pointed piercing elements, e.g. needles, lancets for piercing the skin blade-like piercing elements A61B5/150442
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/15107 Piercing being assisted by a triggering mechanism
• CPC Class Codes: A61B 5/15117 comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
• CPC Class Codes: A61B 5/15121 comprising piezos
• CPC Class Codes: A61B 5/15123 comprising magnets or solenoids
• CPC Class Codes: A61B 5/15142 Devices intended for single use, i.e. disposable

Abstract

This invention provides devices and methods for obtaining a sample.

Claims

1. A sampling device comprising:

a capillary tube and a lancing or cutting implement present inside said capillary tube, wherein said lancing element is capable of breaking a layer of skin sufficiently to draw a sample from a subject.

2. The sampling device of claim 1, wherein said capillary tube comprises at least one end which is open or capable of being open.

3. The sampling device of claim 1, further comprising at least one impulse component operably linked to said capillary tube and said lancing or cutting implement.

4. The sampling device of claim 1, wherein said capillary tube is coated with one or more reagents.

5. The sampling device of claim 1, wherein said capillary tube has a capacity of from about 20 μ

l to about 1000 μ

l.

6. The sampling device of claim 1, further comprising a sleeve into which said capillary tube is inserted and comprising an open end which forms a seal around a subject'"'"'s skin.

7. The sampling device of claim 1, wherein said breaking is through a cut or a piercing of said skin.

8. The sampling device of claim 3, wherein said impulse component is spring-actuated, electromagnetic or piezoelectric.

9. The sampling device of claim 4, wherein said one or more reagents is an anticoagulant(s).

10. The sampling device of claim 6, comprising at least two impulse components, wherein one of said impulse components extends said capillary tube and another of said impulse components extends said lancing or cutting implement.

11. The sampling device of claim 6, wherein said device is capable of providing vacuum suction in said capillary.

12. The sampling device of claim 10, wherein said second impulse component is capable of impelling said lancing implement to a position of about 0.5 mm, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, or 6 mm outside an open end of said capillary tube.

13. The sampling device of claim 11, wherein said subject'"'"'s skin is on a finger, a heel or a toe.

14. A method of obtaining a sample from a subject comprising:

contacting skin of said subject with a sampling device comprising a capillary tube comprising a cutting or lancing implement to said subject'"'"'s skin, breaking the subject'"'"'s skin with said lancing implement and flowing blood from said break into said capillary.

15. The method of claim 14, wherein sampling device further comprises at least one impulse component, said impulse component operating to impel said capillary and cutting or lancing implement to said subject'"'"'s skin, wherein said contacting comprises actuating said impulse device.

16. The method of claim 15, wherein said at least one impulse component extends the cutting or piercing implement in a jabbing motion to cut or pierce the skin.

17. The method of claim 15, comprising at least two impulse components, wherein one of said one or more impulse components actuates said capillary and wherein a second of said one or more impulse components actuates said lancing implement.

18. The method of claim 14, wherein said capillary is coated with one or more reagents.

19. The method of claim 14, wherein said capillary is coated with one or more anti-coagulants.

20. The method of claim 14, wherein said sampling device further comprises a sleeve which surrounds said subject'"'"'s skin.

21. The method of claim 14, wherein said sampling device is capable of holding from about 20 ul to about 1 ml of said sample.

22. The method of claim 20, wherein said skin surrounded by said sleeve comprises a subject'"'"'s appendage.

23. The method of claim 20, wherein said device provides vacuum suction.

24. A method of obtaining a sample from a subject comprising:

contacting skin of said subject with a sampling device comprising a capillary tube comprising an edge for breaking the subject'"'"'s skin to allow blood flow into said capillary.

25. The method of claim 24, wherein said capillary tube is pushed forward into the skin by an impulse component.