CATHETER WITH FILTERING AND SENSING ELEMENTS

• US 20080097339A1
• Filed: 08/31/2006
• Published: 04/24/2008
• Est. Priority Date: 08/31/2006
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Medrad Incorporated (Bayer AG)
• Inventors: Ranchod, Arun, Griffiths, David M., Hirschman, Alan D.
• Granted Patent: US 8,876,754 B2
• Time in Patent Office: Days
• US Class Current: 604/246
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked

Abstract

In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.

Claims

1. An apparatus for infusing a therapeutic agent into a body lumen, comprising:

a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen; and

a sensing element distal of the at least one infusion port and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen.

2. An apparatus as claimed in claim 1, comprising a feedback component associated with the sensing element and adapted to provide a sensing element signal to a location outside of the body lumen.

3. An apparatus as claimed in claim 2, wherein the feedback component provides the sensing element signal to a user interface.

4. An apparatus as claimed in claim 2, wherein the sensing element signal is represented to a user as an audible, visual, or tactile stimulus or a combination stimulus comprising one or more of the audible, visual, and tactile stimuli.

5. An apparatus as claimed in claim 2, wherein the sensing element signal is proportional to the amount of therapeutic agent or derivative thereof sensed by the sensing element.

6. An apparatus as claimed in claim 1, wherein the sensing element is adapted to sense the amount of therapeutic agent or derivative thereof by one or more of resonant mass detection, light reflectance, and electrical conductivity changes.

7. An apparatus as claimed in claim 1, wherein the sensing element is shaped to correspond to the cross-sectional shape of the body lumen.

8. An apparatus as claimed in claim 1, wherein the sensing element is formed as a fine wire mesh.

9. An apparatus as claimed in claim 1, wherein the sensing element is formed of electrically conductive material.

10. An apparatus as claimed in claim 9, wherein the electrically conductive material is formed as a fine wire mesh adapted to intercept at least some of the therapeutic agent or derivative thereof in the body lumen.

11. An apparatus as claimed in claim 9, wherein the electrically conductive material changes conductivity when exposed to the therapeutic agent or derivative thereof.

12. An apparatus as claimed in claim 1, comprising a filtration element disposed distal of the at least one infusion port and proximal of the sensing element.

13. An apparatus as claimed in claim 12, wherein the filtration element comprises a plurality of generally tree-shaped structures.

14. An apparatus for infusing a therapeutic agent into a body lumen, comprising:

a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen; and

a filtration element distal of the at least one infusion port and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen.

15. An apparatus as claimed in claim 14, wherein the filtration element is coated with the reaction agent.

16. An apparatus as claimed in claim 14, wherein the filtration element comprises a plurality of generally tree-shaped structures.

17. An apparatus as claimed in claim 16, wherein the generally tree-shaped structures are coated with the reaction agent.

18. An apparatus as claimed in claim 14, wherein the filtration element is in the form of at least one distal infusion port disposed distal of the lumenal body.

19. An apparatus as claimed in claim 18, comprising a sensing element distal of the at least one distal infusion port.

20. An apparatus as claimed in claim 14, comprising a sensing element distal of the filtration element and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in response to the reaction agent in the body lumen.

21. An apparatus as claimed in claim 20, comprising a feedback component associated with the sensing element and adapted to provide a sensing element signal to a location outside of the body lumen.

22. An apparatus as claimed in claim 21, wherein the feedback component is adapted to communicate wirelessly with a user interface located outside of the body lumen.

23. An apparatus as claimed in claim 21, wherein the feedback component provides the sensing element signal to a user interface.

24. An apparatus as claimed in claim 21, wherein the sensing element signal is represented to a user as an audible, visual, or tactile stimulus or a combination stimulus comprising one or more of an audible, visual, and tactile stimuli.

25. An apparatus as claimed in claim 21, wherein the sensing element signal is proportional to the amount of therapeutic agent or derivative thereof sensed by the sensing element.

26. An apparatus as claimed in claim 20, wherein the sensing element is adapted to sense the amount of therapeutic agent or derivative thereof by one or more of resonant mass detection, light reflectance, and electrical conductivity changes.

27. An apparatus as claimed in claim 20, wherein the sensing element is formed as a fine wire mesh.

28. An apparatus as claimed in claim 20, wherein the sensing element is formed of electrically conductive material.

29. An apparatus as claimed in claim 28, wherein the electrically conductive material is formed as a fine wire mesh adapted to intercept at least some of the therapeutic agent or derivative thereof in the body lumen.

30. An apparatus as claimed in claim 28, wherein the electrically conductive material changes conductivity when exposed to the therapeutic agent or derivative thereof.

31. A sensing element for use with a lumenal body used to deliver a therapeutic agent to a body lumen, comprising an electrically conductive body adapted to change conductivity when exposed to the therapeutic agent or any compound derived from the therapeutic agent.

32. A sensing element as claimed in claim 31, wherein the body is in the form of an electrically conductive fine wire mesh.

33. A sensing element as claimed in claim 31, wherein the body is shaped to correspond to the cross-sectional shape of the body lumen.

34. A sensing element as claimed in claim 31, wherein the sensing element comprises a feedback component adapted to provide a sensing element signal to a location outside of the body lumen.

35. A sensing element as claimed in claim 34, wherein the sensing element comprises a user interface coupled to the feedback component for receiving the sensing element signal.

36. A sensing element as claimed in claim 35, wherein the user interface is adapted to represent the sensing element signal to a user as an audible, visual, or tactile stimulus or a combination stimulus comprising one or more of the audible, visual, and tactile stimuli.

37. A sensing element as claimed in claim 34, wherein the sensing element signal is proportional to the amount of therapeutic agent or derivative thereof sensed by the sensing element.

38. A sensing element as claimed in claim 31, wherein the sensing element is adapted to sense a combination of the therapeutic agent and a reaction agent adapted to react with the therapeutic agent.

40. A filtration element as claimed in claim 38, wherein the coated structures are generally tree-shaped.

39. A filtration element for use with a lumenal body used to deliver a therapeutic agent to a body lumen comprising a plurality of structures coated with a reaction agent adapted to react with the therapeutic agent.