Methods of fabricating microneedles with bio-sensory functionality

• US 20080097352A1
• Filed: 09/12/2006
• Published: 04/24/2008
• Est. Priority Date: 09/12/2006
• Status: Abandoned Application

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Zhang, Xio-An Sean, Beck, Patricia A., Raju, Ramesh Govinda
• Application Number:
  US11/520,526
• Publication Number:
  US 20080097352A1
• Time in Patent Office: Days
• US Class Current: 604/272
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/685 Microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: B81B 2201/055 Microneedles
• CPC Class Codes: B81C 1/00111 Tips, pillars, i.e. raised structures microneedles A61M37/0015
• CPC Class Codes: B81C 2201/0197 Processes for making multi-layered devices not provided for in groups B81C2201/0176 - B81C2201/0192
• CPC Class Codes: Y10T 29/49204 Contact or terminal manufacturing

Abstract

A method of fabricating a microneedle is disclosed. The method includes forming at least one recess in a substrate, the at least one recess comprising an apex, forming an electrically seed layer on the substrate including the at least one recess, forming at least one electrically nonconductive pattern on a portion of the seed layer, the at least one nonconductive pattern being a pattern for a sensory area, plating an electrically conductive material on the seed layer to create a plated layer with an opening that exposes a portion of the nonconductive pattern and separating the plated layer from the seed layer and the at least one nonconductive pattern to release a hollow microneedle comprising a tip and at least one sensory area.

Claims

1. A method of fabricating a microneedle, said method comprising:

(a) forming at least one recess in a substrate, the at least one recess comprising an apex;

(b) forming an electrically conductive seed layer on the substrate including the at least one recess;

(c) forming at least one electrically nonconductive pattern on a portion of the seed layer, the at least one nonconductive pattern being a pattern for a sensory area;

(d) plating an electrically conductive material on the seed layer to create a plated layer with an opening that exposes a portion of the nonconductive pattern; and

(e) separating the plated layer from the seed layer and the at least one nonconductive pattern to release a hollow microneedle comprising a tip and at least one sensory area.

2. The method of claim 1 wherein the sensory area comprises a channel.

3. The method of claim 1 wherein the at least one recess comprises a plurality of recesses, each of the plurality of recesses comprising an apex wherein the act of forming at least one nonconductive pattern on a portion of the seed layer further comprises:

forming at least one nonconductive pattern on a sidewall of one of the plurality of recesses.

4. The method of claim 1 wherein the substrate includes at least one patterned protrusion.

5. The method of claim 1 wherein another of the at least one nonconductive pattern is not on the recess.

6. The method of claim 3 wherein the act of forming at least one nonconductive pattern on a sidewall of one of the plurality of recesses further comprises:

forming at least one nonconductive pattern on both sidewalls of one of the plurality of recesses.

7. The method of claim 4 wherein the at least one sensory area comprises multiple sensory areas around the interior circumference of the hollow microneedle.

8. The method of claim 5 wherein the another of the at least one nonconductive pattern are on either side of the recess.

9. The method of claim 1 wherein forming at least one electrically nonconductive pattern on a portion of the seed layer further comprises:

dispersing non-conductive nano particles into a conductive material to form a solution.

10. A hollow plated microneedle comprising:

a base;

a hollow tip;

an opening laterally offset from the tip; and

at least one sensory area.

11. The microneedle of claim 10 wherein the at least one sensory area comprises a channel.

12. The microneedle of claim 10 wherein the at least one sensory area comprises two sensory areas in the base wherein each of the two sensory areas are on either side of the hollow tip.

13. The microneedle of claim 10 wherein the at least one sensory area comprises a plurality of sensory channels wherein at least one of the plurality of sensory channels is on an exterior side of the base and at least one of the plurality of sensory channels is on an interior side of the base.

14. The microneedle of claim 10 wherein the at least one sensory area is on an interior sidewall of the hollow tip.

15. The microneedle of claim 10 further comprising an inner surface and an outer surface whereby the inner surface includes a sensory area.

16. A method of performing a biosensory function comprising:

utilizing a hollow microneedle to perform the biosensory function.

17. The method of claim 16 wherein the hollow microneedle includes at least one sensory area and utilizing the hollow microneedle to perform the biosensory function:

functionalizing the at least one sensory area to become reactive to a predetermined agent.

18. The method of claim 16 wherein the at least one sensory area comprises a channel.

19. The method of claim 16 wherein the hollow microneedle includes a tip and utilizing the hollow microneedle to perform the biosensory function further comprises:

coupling sensors to the microneedle; and

using the sensors to detect a flow or presence of an a desired agent.

20. The method of claim 17 wherein functionalizing the at least one sensory area further comprises:

functionalizing the at least one sensory area to function in a hydrophobic fashion.

21. The method of claim 17 wherein functionalizing the at least one sensory area further comprises:

functionalizing the at least one sensory area to function in a hydrophilic fashion.

22. A hollow plated microneedle comprising:

a base;

a hollow tip;

an opening laterally offset from the tip; and

micro/nano porous channels.