METHOD AND APPARATUS FOR PREDICTING ACUTE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY
First Claim
1. A method for predicting acute response to cardiac resynchronization therapy, comprising:
- delivering ventricular pacing to a selected stimulation site at a specified AV delay with respect to an atrial sense or pace;
varying the specified AV delay used to deliver the ventricular pacing over a plurality of cardiac cycles;
measuring the duration of ventricular depolarization for different specified AV delays; and
, classifying the stimulation site as non-responsive to cardiac resynchronization therapy if the variation in the duration of ventricular depolarization for the different specified AV delays exceeds a specified threshold.
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Abstract
A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.
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Citations
14 Claims
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1. A method for predicting acute response to cardiac resynchronization therapy, comprising:
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delivering ventricular pacing to a selected stimulation site at a specified AV delay with respect to an atrial sense or pace;
varying the specified AV delay used to deliver the ventricular pacing over a plurality of cardiac cycles;
measuring the duration of ventricular depolarization for different specified AV delays; and
,classifying the stimulation site as non-responsive to cardiac resynchronization therapy if the variation in the duration of ventricular depolarization for the different specified AV delays exceeds a specified threshold. - View Dependent Claims (2, 3, 4, 5)
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6. A system for predicting a patient'"'"'s acute response to cardiac resynchronization therapy, comprising:
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an implantable cardiac device configured to deliver ventricular pacing at a specified AV delay with respect to an atrial sense or pace;
an external programmer in communication with the implantable cardiac device;
wherein the external programmer is configured to;
transmit commands to the implantable cardiac device that vary the specified AV delay used to deliver the ventricular pacing over a plurality of cardiac cycles;
measure the duration of ventricular depolarization for different specified AV delays; and
,classify the patient as a non-responder to cardiac resynchronization therapy if the variation in the duration of ventricular depolarization for the different specified AV delays exceeds a specified threshold. - View Dependent Claims (7, 8, 9, 10)
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11. A device for delivering cardiac resynchronization therapy, comprising:
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circuitry for detecting cardiac electrical activity;
circuitry for delivering ventricular pacing at a specified AV delay with respect to an atrial sense or pace;
circuitry for varying the specified AV delay used to deliver the ventricular pacing over a plurality of cardiac cycles;
circuitry for measuring the duration of ventricular depolarization for different specified AV delays; and
,circuitry for classifying the patient as a non-responder to cardiac resynchronization therapy if the variation in the duration of ventricular depolarization for the different specified AV delays exceeds a specified threshold. - View Dependent Claims (12, 13, 14)
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Specification