ANTIMICROBIAL CONTACT LENSES WITH REDUCED HAZE AND PREPARATION THEREOF

• US 20080100797A1
• Filed: 10/25/2007
• Published: 05/01/2008
• Est. Priority Date: 10/31/2006
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Alvarez-Carrigan, Nayiby, Rathore, Osman
• Application Number:
  US11/923,708
• Publication Number:
  US 20080100797A1
• Time in Patent Office: Days
• US Class Current: 351/160R
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08J 7/12 Chemical modification
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

This invention relates to antimicrobial lenses containing metals and methods for their production.

Claims

1. A method of preparing an antimicrobial lens comprising a metal salt, wherein said method comprises the steps of

(a) treating a cured lens, with a solution comprising salt precursor, and

(b) treating the lens of step (a) with a solution comprising a metal agent, wherein the molar ratio of said metal agent in its solution to the molar ratio of said salt precursor in its solution is greater than about 0.2.

2. The method of claim 1 wherein the molar ratio is about 0.2 to about 10.0

3. The method of claim 1 wherein the molar ratio is about 0.4 to about 2.4.

4. The method of claim 1 wherein the molar ratio is about 0.6 to about 2.4

5. The method of claim 1 wherein the molar ratio is about 0.8 to about 2.4

6. The method of claim 1 wherein the metal salt is silver iodide, the salt precursor is sodium iodide and the metal agent is silver nitrate.

7. The method of claim 2 wherein the molar ratio is about 0.2 to about 10.0.

8. A method of preparing an antimicrobial lens comprising a metal salt, wherein said method comprises the steps of

(a) treating a cured lens, with a solution comprising a metal agent, and

(b) treating the lens of step (a) with a solution comprising a salt cursor, wherein the molar ratio of said metal agent in its solution to the molar ratio of said salt precursor in its solution is greater than about 0.2.

9. The method of claim 8 wherein the metal salt is silver iodide, the salt precursor is sodium iodide and the metal agent is silver nitrate.

10. The method of claim 9 wherein the molar ratio is about 0.2 to about 10.0.

11. An antimicrobial lens comprising a metal salt, made by a method comprising the steps of

(a) treating a cured lens, with a solution comprising salt precursor, and

(b) treating the lens of step (a) with a solution comprising a metal agent, wherein the molar ratio of said metal agent in its solution to the molar ratio of said salt precursor in its solution is greater than about 0.2.

12. The antimicrobial lens of claim 11 wherein the metal salt is silver iodide, the salt precursor is sodium iodide and the metal agent is silver nitrate.

13. The antimicrobial lens of claim 12 wherein the molar ratio is about 0.2 to about 10.0.

14. An antimicrobial lens comprising a metal salt, made by a method comprising the steps of

(a) treating a cured lens, with a solution comprising a metal agent, and

(b) treating the lens of step (a) with a solution comprising a salt precursor, wherein the molar ratio of said metal agent in its solution to the molar ratio of said salt precursor in its solution is greater than about 0.2.

15. The antimicrobial lens of claim 14 wherein the metal salt is silver iodide, the salt precursor is sodium iodide and the metal agent is silver nitrate.

16. The antimicrobial lens of claim 15 wherein the molar ratio is about 0.2 to about 10.0.