PREPARATION FOR THE PROPHYLAXIS OF RESTENOSIS
First Claim
1. A preparation containing at least one antihyperplastic agent with a distribution ratio between butanol and water of ≧
- 0.5 in liquid form suitable for passing through capillaries together with an agent for enhancing artery/vein imaging.
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Accused Products
Abstract
The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
180 Citations
15 Claims
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1. A preparation containing at least one antihyperplastic agent with a distribution ratio between butanol and water of ≧
- 0.5 in liquid form suitable for passing through capillaries together with an agent for enhancing artery/vein imaging.
- View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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2. A preparation containing at least one antihyperplastic agent with a distribution ratio between butanol and water of ≧
- 0.5 that is applied to a catheter.
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3. A preparation in aqueous solution that may optionally contain additives as well as at least one antihyperplastic agent with a distribution ratio between butanol and water of ≧
- 0.5 at a concentration that exceeds the saturation concentration in the purely aqueous medium wherein the active agent is not enclosed in micelles.
Specification