PROCESSES TO PREPARE ANTIMICROBIAL CONTACT LENSES

• US 20080102100A1
• Filed: 10/26/2007
• Published: 05/01/2008
• Est. Priority Date: 10/31/2006
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Balasubramanian, Kanda, Alvarez-Carrigan, Nayiby, Rathore, Osman
• Application Number:
  US11/924,694
• Publication Number:
  US 20080102100A1
• Time in Patent Office: Days
• US Class Current: 424/429
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 31/79 Polymers of vinyl pyrrolidone
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/208 Quaternary ammonium compounds
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

This invention relates to antimicrobial lenses containing metals and methods for their production.

Claims

1. A method of preparing an antimicrobial lens comprising a metal salt, wherein said method comprises the steps of

(a) treating a cured lens, with a salt precursor and

(b) treating the lens of step (a) with a dispersing agent and a metal agent.

2. The method of claim 1 wherein the dispersing agent is selected from the group consisting of polyvinylpyrrolidone, polyvinylalcohol, glycerine and polyethylene oxide.

3. The method of claim 1 wherein the dispersing agent is selected form the group consisting of PVP K-12, PVP K-30, PVP K-60, and PVP K-90.

4. The method of claim 1 wherein the dispersing agent is PVP K-90.

5. The method of claim 1 wherein the salt precursor is selected from the group consisting of sodium chloride, sodium iodide, potassium iodide, sodium bromide, lithium chloride, lithium sulfide, sodium sulfide, potassium sulfide, sodium tetrachloro argentite, tetra-alkyl ammonium lactate, tetra-alkyl ammonium sulfate, tetra-alkyl ammonium chloride, tetra-alkyl ammonium bromide and tetra-alkyl ammonium iodide.

6. The method of claim 1 wherein the salt precursor is sodium iodide.

7. The method claim 1 wherein the metal agent is selected from the group consisting of silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

8. The method of claim 1 wherein the metal agent is silver nitrate.

9. The method of claim 1 wherein the metal salt is selected from the group consisting of manganese sulfide, zinc oxide, zinc sulfide, copper sulfide, copper phosphate, silver nitrate, silver sulfate, silver iodate, silver carbonate, silver phosphate, silver sulfide, silver chloride, silver bromide, silver iodide, and silver oxide.

10. The method of claim 1 wherein the metal salt is selected from the group consisting of silver nitrate, silver sulfate, silver iodate, silver carbonate, silver phosphate, silver sulfide, silver chloride, silver bromide, silver iodide, and silver oxide.

11. The method of claim 1 wherein the metal salt is silver iodide.

12. A method of preparing an antimicrobial lens comprising a metal salt, wherein the method comprises the steps of

(a) treating a cured lens with a metal agent and a dispersing agent;

(b) treating the lens of step (a) with a salt precursor.

13. The method of claim 12 wherein the dispersing agent is selected from the group consisting of polyvinylpyrrolidone, polyvinylalcohol, glycerine and polyethylene oxide.

14. The method of claim 12 wherein the dispersing agent is selected form the group consisting of PVP K-12, PVP K-30, PVP K-60, and PVP K-90.

15. The method of claim 12 wherein the dispersing agent is PVP K-90.

16. The method of claim 12 wherein the salt precursor is selected from the group consisting of sodium chloride, sodium iodide, sodium bromide, lithium chloride, lithium sulfide, potassium iodide, sodium sulfide, potassium sulfide, sodium tetrachloro argentite, tetra-alkyl ammonium lactate, tetra-alkyl ammonium sulfate, tetra-alkyl ammonium chloride, tetra-alkyl ammonium bromide and tetra-alkyl ammonium iodide.

17. The method of claim 12 wherein the salt precursor is sodium iodide.

18. The method claim 12 wherein the metal agent is selected from the group consisting of silver nitrate, silver triflate, silver acetate, silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

19. The method of claim 12 wherein the metal agent is silver nitrate.

20. The method of claim 12 wherein the metal salt is selected from the group consisting of manganese sulfide, zinc oxide, zinc sulfide, copper sulfide, copper phosphate, silver nitrate, silver sulfate, silver iodate, silver carbonate, silver phosphate, silver sulfide, silver chloride, silver bromide, silver iodide, and silver oxide.

21. The method of claim 12 wherein the metal salt is selected from the group consisting of silver nitrate, silver sulfate, silver iodate, silver carbonate, silver phosphate, silver sulfide, silver chloride, silver bromide, silver iodide, and silver oxide.

22. The method of claim 12 wherein the metal salt is silver iodide.

23. A method of preparing an antimicrobial lens comprising a metal salt, wherein the method comprises the steps of

(a) treating a cured lens with a metal agent and a dispersing agent;

and

(b) treating the lens of step (a) with a salt precursor and a dispersing agent;

24. A method of preparing an antimicrobial lens comprising a metal salt, wherein said method comprises the steps of

(a) treating a cured lens, with a salt precursor and a dispersing agent and

(b) treating the lens of step (a) with a dispersing agent and a metal agent.

25. An antimicrobial lens comprising a metal salt made by a method, wherein said method comprises the steps of

(a) treating a cured lens, a salt precursor;

and

(b) treating the lens of step (a) with a dispersing agent and a metal agent.