Composition and method for etiological treatment and prevention of diseases and/or complications associated with chronic glucose metabolism destabilization

• US 20080102137A1
• Filed: 10/31/2006
• Published: 05/01/2008
• Est. Priority Date: 10/31/2006
• Status: Abandoned Application

• Current Assignee: Manning V.R. Guffey
• Original Assignee: Manning V.R. Guffey
• Inventors: Guffey, Manning V.R.
• Application Number:
  US11/590,264
• Publication Number:
  US 20080102137A1
• Time in Patent Office: Days
• US Class Current: 424/641
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/26 Iron; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A natural composition formulated to modulate multiple pathophysiological processes in order to facilitate homeostatic glucose metabolism in a patient, and more particularly to increase insulin sensitivity in the same. The natural composition is a safe and effective formulation for the etiological prevention and treatment of diseases, complications, conditions, or disorders associated with chronic or long-term destabilization of glucose metabolism.

Claims

1. A natural composition adapted to modulate multiple pathophysiological processes in order to facilitate homeostatic glucose metabolism as a method for the etiological prevention and treatment of diseases, complications, conditions, or disorders associated with chronic or long-term destabilization of glucose metabolism, said natural composition comprising:

(a) vitamins;

(b) fatty acids;

(c) amino acids;

(d) phytochemicals;

(e) trace minerals;

(f) antioxidants; and

(g) metals.

2. The natural composition in accordance with claim 1, wherein said natural composition is adapted so as to be administered in solid or liquid form, thereby allowing for various delivery means or delivery systems to be utilized for delivering said natural composition.

3. The natural composition in accordance with claim 1, wherein said delivery systems include oral administration, injection, topical, and nasal spray.

4. The natural composition in accordance with claim 1, wherein said vitamins comprise:

(a) thiamin;

(b) riboflavin;

(c) niacin;

(d) pantothenic acid;

(e) pyridoxine;

(f) folic acid;

(g) cyanocobalamin;

(h) calciferol; and

(i) biotin.

5. The natural composition in accordance with claim 1, wherein said fatty acids comprise:

(a) alpha-lipoic acid; and

(b) conjugated linoleic acid.

6. The natural composition in accordance with claim 1, wherein said amino acids comprise:

(a) L-arginine;

(b) L-carnitine;

(c) L-taurine;

(d) L-alanine;

(e) L-leucine;

(f) L-valine; and

(g) L-isoleucine.

7. The natural composition in accordance with claim 1, wherein said phytochemicals comprise:

(a) siberian eleuthero root;

(b) astragalus membranaceus;

(c) ginseng;

(d) acerola berry powder;

(e) cinnamon;

(f) flaxseed powder or lignans; and

(g) spirulina.

8. The natural composition in accordance with claim 1, wherein said trace minerals comprise:

(a) chromium;

(b) vanadium; and

(c) zinc.

9. The natural composition in accordance with claim 1, wherein said antioxidants comprise:

(a) tocopherol;

(b) beta-carotene;

(c) ubiquinone;

(d) Iycopene;

(e) ascorbic acid;

(f) tetrahydrobiopterin;

(g) N-acetylcysteine;

(h) selenium; and

(i) a high oxygen radical absorbance capacity blend.

10. The natural composition in accordance with claim 1, wherein said metals comprise:

(a) magnesium; and

(b) calcium.

11. The natural composition in accordance with claim 4, wherein:

(a) said thiamin is in an amount ranging from about 10 mg to 2000 mg;

(b) said riboflavin is in an amount ranging from about 10 mg to 2000 mg;

(c) said niacin is in an amount ranging from about 10 mg to 2000 mg;

(d) said pantothenic acid is in an amount ranging from about 10 mg to 2000 mg;

(e) said pyridoxine is in an amount ranging from about 10 mg to 2000 mg;

(f) said folic acid is in an amount ranging from about 0.1 mg to 50 mg;

(g) said cyanocobalamin is in an amount ranging from about 0.005 mg to 0.1 mg;

(h) said calciferol is in an amount ranging from about 0.001 mg to 0.020 mg; and

(i) said biotin is in an amount ranging from about 0.1 mg to 1 mg.

12. The natural composition in accordance with claim 5, wherein:

(a) said alpha-lipoic acid is in an amount ranging from about 5 mg to 50 mg; and

(b) said conjugated linoleic acid is in an amount ranging from about 50 mg to 800 mg.

13. The natural composition in accordance with claim 6, wherein:

(a) said L-arginine is in an amount ranging from about 65 mg to 3250 mg;

(b) said L-carnitine is in an amount ranging from about 75 mg to 2700 mg;

(c) said L-taurine is in an amount ranging from about 50 mg to 3125 mg;

(d) said L-alanine is in an amount ranging from about 60 mg to 3000 mg;

(e) said L-leucine is in an amount ranging from about 25 mg to 1000 mg;

(f) said L-valine is in an amount ranging from about 20 mg to 1100 mg; and

(g) said L-isoleucine is in an amount ranging from about 30 mg to 1500 mg.

14. The natural composition in accordance with claim 7, wherein:

(a) said siberian eleuthero root is in an amount ranging from about 50 mg to 850 mg;

(b) astragalus membranaceus is in an amount ranging from about 40 mg to 750 mg;

(c) ginseng is in an amount ranging from about 10 mg to 1000 mg;

(d) acerola berry powder is in an amount ranging from about 50 mg to 900 mg;

(e) cinnamon is in an amount ranging from about 100 mg to 1000 mg;

(f) said flaxseed powder is in an amount ranging from about 5 mg to 1000 mg;

(g) said lignans is in an amount ranging from about 4 mcg to 800 mcg; and

(g) said spirulina is in an amount ranging from about 20 mg to 1200 mg.

15. The natural composition in accordance with claim 8, wherein said chromium is in the form of a member or combination thereof selected from the group consisting of chromium picolinate, chromium nicotinate, chromium dinicotinate, chromium tripicolinate, and chromium polynicotinate.

16. The natural composition in accordance with claim 15, wherein:

(a) said chromium picolinate is in an amount ranging from about 100 mcg to 1200 mcg;

(b) chromium nicotinate is in an amount ranging from about 100 mcg to 1200 mcg;

(c) said chromium dinicotinate is in an amount ranging from about 100 mcg to 1200 mcg;

(d) said chromium tripicolinate is in an amount ranging from about 100 mcg to 1200 mcg; and

(e) said chromium polynicotinate is an amount ranging from about 25 mcg to 1200 mcg.

17. The natural composition in accordance with claim 8, wherein:

(a) said vanadium is in an amount ranging from about 1 mg to 400 mg; and

(b) said zinc is in an amount ranging from about 0.5 mg to 100 mg.

18. The natural composition in accordance with claim 9, wherein said tocopherol is comprised of a-tocopherol or all-racemic α

-tocopherol.

19. The natural composition in accordance with claim 18, wherein said α

-tocopherol is in an amount ranging from about 5 mg to 500 mg.

20. The natural composition in accordance with claim 18, wherein said all-reacemic α

-tocopherol is in an amount ranging from about 2.55 mg to 400 mg.

21. The natural composition in accordance with claim 9, wherein:

(a) said beta-carotene is in an amount ranging from about 10 mg to 50 mg;

(b) said ubiquinone is in an amount ranging from about 3 mg to 300 mg;

(c) said lycopene is in an amount ranging from about 0.25 mg to 1.25 mg;

(d) said ascorbic acid is in an amount ranging from about 60 mg to 3200 mg;

(e) said tetrahydrobiopterin is in an amount ranging from about 25 mg to 3250 mg;

(f) said N-acetylcysteine is in an amount ranging from about 90 mg to 50 g; and

(g) said selenium is in an amount ranging from about 0.015 mg to 1 mg.

22. The natural composition in accordance with claim 9, wherein said high oxygen radical absorbance capacity blend comprises berry extracts, wherein said berry extracts comprise:

(a) strawberry extract;

(b) blueberry extract;

(c) blackberry extract;

(d) cranberry extract; and

(e) raspberry extract.

23. The natural composition in accordance with claim 22, wherein said high oxygen radical absorbance capacity blend is in an amount ranging from about 5 mg to 100 mg.

24. The natural composition in accordance with claim 10, wherein:

(a) said magnesium is in an amount ranging from about 15 mg to 1100 mg; and

(b) said calcium is in an amount ranging from about 5 mg to 750 mg.

25. The natural composition in accordance with claim 8, wherein said trace minerals further comprise:

(a) iodine;

(b) copper;

(c) manganese; and

(d) molybdenum.

26. The natural composition in accordance with claim 25, wherein:

(a) said iodine is in an amount ranging from about 25 mcg to 200 mcg;

(b) said copper is in an amount ranging from about 0.5 mg to about 4 mg;

(c) said manganese is in an amount ranging from about 0.5 mg to about 4 mg; and

(d) said molybdenum is in an amount ranging from about 25 mcg to 125 mcg.

27. The natural composition in accordance with claim 1, wherein said natural composition further comprises cell messenger agents.

28. The natural composition in accordance with claim 27, wherein said cell messenger agents comprise:

(a) inositol; and

(b) choline.

29. The natural composition in accordance with claim 28, wherein:

(a) said inositol is in an amount ranging from about 1 mg to 600 mg; and

(b) said choline is in an amount ranging from about 1 mg to 600 mg.

30. The natural composition in accordance with claim 28, wherein said cell messenger agents further comprise:

(a) boron;

(b) silica; and

(c) lutein.

31. The natural composition in accordance with claim 30, wherein:

(a) said boron is in an amount ranging from about 0.025 mg to about 50 mg;

(b) said silica is in an amount ranging from about 0.025 mg to about 100 mg; and

(c) said lutein is in an amount ranging from about 100 mcg to about 5 mg.

32. The natural composition in accordance with claim 1, wherein said natural composition further comprises one or more growth factors, wherein said one or more growth factors are adapted and formulated as an adjunct to said natural composition as a method to facilitate effective treatment of diseases, complications, conditions, or disorders including diabetes, inflammation, joint and muscle pain, muscle weakness, fatigue, chronic viral infections, cancer, nasal and sinus congestion, respiratory complications, digestive problems, memory loss, neuropathy, and psychological conditions including depression, mood swings, anger, anxiety, and confusion, and wherein said growth factors are further adapted and formulated to aid in reducing body fat and increasing or maintaining lean body tissue, thereby potentially leading to weight loss.

33. The natural composition in accordance with claim 32, wherein said adjunct is defined as a homeopathic formulation.

34. The natural composition in accordance with claim 33, wherein said homeopathic formulation comprises a molar concentration of between 1×

10⁻

2 and 1×

10⁻

1,250,000 of said one or more growth factors.

35. The natural composition in accordance with Clam 34, wherein said one or more growth factors are selected from the group consisting of:

(a) insulin-like growth factor I (IGF-I);

(b) insulin-like growth factor II (IGF-II);

(c) nerve growth factor (NGF);

(d) stem cell growth factor (SCF);

(e) fibroblast growth factor (FGF);

(f) granulocyte macrophage-colony stimulating growth factor (GM-CSF);

(g) granulocyte-colony stimulating growth factor (G-CSF);

(h) macrophage-colony stimulating growth factor (M-CSF);

(i) transforming growth factor α

(TGFα

);

() transforming growth factor β

(TGβ

P);

(k) platelet-derived growth factor (PDGF);

(I) tumor necrosis factor α

(TNFα

); and

(m) tumor necrosis factor β

(TNFβ

).

36. A natural composition adapted to modulate multiple pathophysiological processes in order to facilitate homeostatic glucose metabolism as a method for the etiological prevention and treatment of diseases, complications, conditions, or disorders associated with chronic or long-term destabilization of glucose metabolism, and wherein said natural composition is further adapted to facilitate effective treatment of diseases, complications, conditions, or disorders including diabetes, inflammation, joint and muscle pain, muscle weakness, fatigue, chronic viral infections, cancer, nasal and sinus congestion, respiratory complications, digestive problems, memory loss, neuropathy, and psychological conditions including depression, mood swings, anger, anxiety, and confusion, said natural composition also adapted to aid in reducing body fat and increasing or maintaining lean body tissue, thereby potentially leading to weight loss, said natural composition comprising:

(a) vitamins;

(b) fatty acids;

(c) amino acids;

(d) phytochemicals;

(e) trace minerals;

(f) antioxidants;

(g) metals;

(h) cell messenger agents; and

(i) one or more growth factors.

37. A method for facilitating homeostatic glucose metabolism in a patient for the etiological treatment and etiological prevention of diseases, complications, conditions, or disorders associated with chronic or long-term destabilization of glucose metabolism, said method comprising:

(a) administering a patient an effective amount or dosage of a natural composition comprising vitamins, fatty acids, amino acids, phytochemicals, trace minerals, antioxidants, and metals.

38. The method in accordance with claim 37, wherein said natural composition further comprises:

(a) cell messenger agents; and

(b) growth factors.