BIOLOGICAL TISSUE FOR SURGICAL IMPLANTATION
First Claim
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1. A method of treating a biological tissue, the method comprising:
- contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol; and
removing a portion of the treatment solution from the solution-treated biological tissue.
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Abstract
A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.
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Citations
17 Claims
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1. A method of treating a biological tissue, the method comprising:
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contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol; and removing a portion of the treatment solution from the solution-treated biological tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A sealed package containing a sterilized solution-treated, biological tissue for surgical implantation into a human, said solution-treated, biological tissue prepared by a process comprising:
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contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol; and removing a portion of the treatment solution from the solution-treated tissue to provide the solution-treated biological tissue.
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11. The sealed package of claim 11 wherein the treatment solution comprises 40% to 95% by volume of a polyhydric alcohol;
- and 5% to 60% by volume of a C1-C3 alcohol.
- View Dependent Claims (12)
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13. A sterilized solution-treated, biological tissue for surgical implantation into a human, said sterilized, solution-treated biological tissue prepared by a process comprising:
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contacting the biological tissue with a treatment solution comprising 40% to 95% by volume of a polyhydric alcohol and 5% to 60% by volume of a C1-C3 alcohol; and removing a portion of the treatment solution from the solution-treated tissue to provide a biological tissue ready for sterilized containment.
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14. The biological tissue of claim 14 wherein the treatment solution comprises 70% to 95% by volume of a polyhydric alcohol;
- and 5% to 30% by volume of a C1-C3 alcohol.
- View Dependent Claims (15)
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16. A heart valve prosthesis comprising:
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a collapsible, elastic valve member, wherein the valve member comprises a biological tissue that is solution-treated, said solution treatment comprising; contacting the biological tissue with a treatment solution comprising 40% to 95% by volume of a polyhydric alcohol and 5% to 60% by volume of a C1-C3 alcohol; and removing a portion of the treatment solution from the solution-treated tissue to provide a biological tissue ready for sterilized containment; an elastic stent member in which the valve member is mounted, the stent member having internal and external surfaces; and a support coupled to the valve member and positioned between the valve member and the stent member, wherein the stent member forms a continuous surface and comprises strut members that provide a structure sufficiently rigid to prevent eversion, and the support extends from the internal surface of the stent member to the external surface of the stent member, and wherein the stent member has sufficient radial and longitudinal rigidity to withstand the radial force necessary for implantation, to resist aortic recoil forces, and to provide long-term support to the valve prosthesis. - View Dependent Claims (17)
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Specification