APPARATUS AND METHODS FOR PERFORMING CELLULAR ELECTRO-MANIPULATIONS
First Claim
1. An intracellular electro-manipulation apparatus for providing electric pulse output to biological cells, the apparatus comprising:
- a pulse generator that generates an ultrashort electric field pulse;
a pulse delivery system that delivers the ultrashort electric field pulse to a target comprising one or more biological cells; and
a reflected-signal impeder connected between the pulse generator and the pulse delivery system for impeding reflection of a signal to the pulse generator when impedance mismatching between the pulse delivery system and pulse generator occurs.
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Accused Products
Abstract
An intracellular electro-manipulation apparatus for delivery an electric field pulse to a target of one or more biological cells is provided. The apparatus includes a pulse generator that generates an ultrashort electric field pulse, and a pulse delivery system that directs the ultrashort electric field pulse to the target. The apparatus can include a reflected-signal impeder connected between the pulse generator and the pulse delivery system to impede reflection of a signal to the pulse generator when impedance mismatching between the pulse delivery system and pulse generator occurs. Alternatively, or additionally, the apparatus can include a current limiter connected between the pulse generator and the pulse delivery system to limit current between the pulse generator and the pulse delivery system when a high-conductivity condition occurs in the target.
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Citations
20 Claims
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1. An intracellular electro-manipulation apparatus for providing electric pulse output to biological cells, the apparatus comprising:
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a pulse generator that generates an ultrashort electric field pulse; a pulse delivery system that delivers the ultrashort electric field pulse to a target comprising one or more biological cells; and a reflected-signal impeder connected between the pulse generator and the pulse delivery system for impeding reflection of a signal to the pulse generator when impedance mismatching between the pulse delivery system and pulse generator occurs. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An intracellular electro-manipulation apparatus for providing electric pulse output to biological cells, the apparatus comprising:
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a pulse generator that generates an ultrashort electric field pulse; a pulse delivery system that delivers the ultrashort electric field pulse to a target comprising one or more biological cells; and a current limiter connected between the pulse generator and the pulse delivery system to limit current between the pulse generator and the pulse delivery system when a high-conductivity condition occurs in the target. - View Dependent Claims (8, 9, 10)
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11. An intracellular electro-manipulation apparatus for providing electric pulse output to biological cells, the apparatus comprising:
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a pulse generator that generates an ultrashort electric field pulse; a pulse delivery system that delivers the ultrashort electric field pulse to a target comprising one or more biological cells; a reflected-signal impeder connected between the pulse generator and the pulse delivery system for impeding reflection of a signal to the pulse generator when impedance mismatching between the pulse delivery system and pulse generator occurs; and a current limiter connected between the pulse generator and the pulse delivery system to limit current between the pulse generator and the pulse delivery system when a high-conductivity condition occurs in the target. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of intracellular electro-manipulation, the method comprising:
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generating an ultrashort electric field pulse using a pulse generator; delivering the ultrashort electric field pulse to a target using a pulse delivery system, the target comprising one or more biological cells; if impedance mismatching between the pulse delivery system and pulse generator occurs, impeding reflection of a signal to the pulse generator using a reflected-signal impeder; and if a high-conductivity condition occurs in the target, limiting current between the pulse generator and the pulse delivery system using a current limiter.
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Specification