METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS
First Claim
1. A method for treating a patient having a neurological condition, comprising:
- identifying one or more neural populations associated with the condition, including a cortical target neural population;
comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the parameter; and
if the patient-specific measure differs from the target measure by at least a target amount;
selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure; and
applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.
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Accused Products
Abstract
Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.
179 Citations
79 Claims
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1. A method for treating a patient having a neurological condition, comprising:
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identifying one or more neural populations associated with the condition, including a cortical target neural population;
comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the parameter; and
if the patient-specific measure differs from the target measure by at least a target amount;
selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure; and
applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A method for treating a depressed patient, comprising:
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detecting a patient-specific characteristic parameter for a selected neural population, the selected neural population including Brodman area 9 or Brodman area 25;
comparing the detected measure of the characteristic parameter with a target measure for the parameter; and
if the detected measure differs from the target measure by at least a target amount;
selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the characteristic parameter; and
applying electrical signals to the patient'"'"'s cortex at Brodman area 9 at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the detected measure and the target measure and reduce the depression. - View Dependent Claims (59, 60)
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61. A method for treating a patient having a neurological condition, comprising:
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identifying one or more neural populations associated with the condition, including a cortical target neural population;
comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the parameter; and
if the patient-specific measure differs from the target measure by at least a target amount;
selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the nature of the condition; and
applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure. - View Dependent Claims (62, 63, 64)
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65. A method for treating a patient having a neurological condition, comprising:
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identifying one or more neural populations associated with the condition, including a cortical target neural population;
comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the parameter; and
if the patient-specific measure differs from the target measure by at least a target amount;
selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on (a) the difference between the patient-specific measure and the target measure, (b) the nature of the condition, or (c) both (a) and (b); and
applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure. - View Dependent Claims (66, 67, 68, 69, 70)
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71. A computer-implemented method for treating a patient having a neurological condition, comprising:
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receiving an identity of the condition;
receiving an identity of one or more neural populations associated with the condition, including a cortical target neural population;
receiving a patient-specific measure of a characteristic parameter for a selected one of the neural populations;
comparing the patient-specific measure of the characteristic parameter with a target measure for the parameter; and
if the patient-specific measure differs from the target measure by at least a target amount, selecting a signal polarity, frequency, or both polarity and frequency for electrical signals to be applied to the target neural population, based at least in part on the difference between the patient-specific measure and the target measure. - View Dependent Claims (72, 73, 74)
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75. An apparatus for effectuating a neural function of a patient comprising:
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a response trigger positionable to deliver a stimulus to a patient;
a response detector operatively coupleable to the patient to receive a response indicative of a neuropsychiatric dysfunction from the patient resulting from operation of the response trigger;
a processor coupled to the response detector to receive information corresponding to the patient'"'"'s response, the processor being programmed with instructions to provide signal delivery parameters including signal polarity, frequency, or both, for electromagnetic signals applied to the patient, based at least in part on the information received from the response detector, to alter the patient'"'"'s neural functioning; and
a signal delivery device coupled to the patient to provide electromagnetic signals in accordance with the signal delivery parameters. - View Dependent Claims (76, 77, 78, 79)
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Specification