METHOD FOR DISPENSING TABLETS INTO A MULTI-COMPARTMENT CLINICAL REAGENT CONTAINER

• US 20080105516A1
• Filed: 11/03/2006
• Published: 05/08/2008
• Est. Priority Date: 11/03/2006
• Status: Active Grant

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Dade Behring, Inc. (Siemens AG)
• Inventors: Richwine, Dean Charles
• Granted Patent: US 7,386,970 B2
• Time in Patent Office: Days
• US Class Current: 198/771
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/0642 Filling fluids into wells by specific techniques
• CPC Class Codes: B01L 2200/0647 Handling flowable solids, e.g. microscopic beads, cells, particles
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 3/0241 Drop counters; Drop formers making arrays for combinatorial libraries B01J19/0046; automation of dispensing for analysis G01N35/10
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence

Abstract

A method for dispensing a desired number of oriented tablets from a bulk source into a well within a reagent container by moving the tablets by vibration into a number of parallel loading chutes and transfer chutes and displacing the desired number of tablets into a drop chute aligned over the well.

Claims

1. A method for dispensing a desired number of tablets into individual wells within a reagent container, the method comprising:

dispensing a plurality of tablets from a bulk source onto a linear vibrating table;

orienting the tablets to a flat position;

moving the tablets by vibration into a number of loading chutes;

moving the tablets by vibration into a number of transfer chutes;

displacing the desired number of tablets from the transfer chutes into a drop chute aligned over the well, wherein displacing the desired number of tablets from the transfer chutes comprises lifting a first tablet within the transfer chute and moving said first tablet to urge tablets into the drop chute and thereafter, releasing said first tablet into the drop chute, whereby the tablets are deposited into the wells.

2. The method of claim 1 wherein orienting the tables to a flat position comprises moving the tablets by vibration across an orienting zone within the linear vibrating table, the orienting zone having a number of vacuum grooves formed in a generally cross-hatched pattern in the surface thereof.

4. The method of claim 1 wherein lifting said first tablet comprises applying a vacuum to said tablet, the vacuum applied by suction ports on the lower surface of an arm disposed above the loading chutes.

5. The method of claim 4 wherein moving said first tablet to urge the tablets into the drop chute comprises moving said arm above the loading chutes and toward the drop chute while said first tablet is lifted.

6. The method of claim 1 wherein a tablet dislodging system comprising a source of air pressure is located proximate the loading chutes and is configured and operated to dislodge tablets than may be jammed together.

7. The method of claim 1 wherein an optical inspection system is located above the loading chutes and is configured and operated to confirm the presence of tablets therein and to detect the presence of partial or broken tablets.

8. The method of claim 1 wherein the number of loading chutes and the number of transfer chutes is the same number as is the total number of wells within the container wherein tablets may be placed.

9. The method of claim 1 wherein the number of loading chutes and the number of transfer chutes is less than the total number of wells within the container wherein tablets may be placed.

10. The method of claim 1 wherein the same number of tablets is displaced into each drop chute.

11. The method of claim 1 wherein a different number of tablets are displaced into each drop chute.

3. (canceled)

12. A method for dispensing a desired number of tablets into individual wells within a reagent container, the method comprising:

dispensing a plurality of tablets from a bulk source onto a linear vibrating table;

orienting the tablets to a flat position;

moving the tablets by vibration into a number of loading chutes;

moving a full complement of tablets greater than said desired number of tablets by vibration into transfer chutes;

retaining by vacuum all tablets in the transfer chute except said desired number of tablets; and

then,

displacing the desired number of tablets from the transfer chutes into a drop chute aligned over the well, whereby the tablets are deposited into the wells.