Gastric Retention System
First Claim
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1. A gastric retention system in the form of a coated tablet comprising:
- (a) a core in the form of a tablet comprising an agent capable of generating internal pressure on the coat, and(b) an expandable coating formed by applying a coating composition comprising a film-forming polymer and one or more expandable components on the tablet core to form a film capable of expanding and maintaining its physical integrity in the gastric milleu.
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Abstract
The present invention provides a novel gastric retention system in the form of a tablet or a capsule coated with an expandable coating, more particularly, with an expandable coating comprising a film-forming polymer and an expandable component.
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Citations
15 Claims
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1. A gastric retention system in the form of a coated tablet comprising:
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(a) a core in the form of a tablet comprising an agent capable of generating internal pressure on the coat, and (b) an expandable coating formed by applying a coating composition comprising a film-forming polymer and one or more expandable components on the tablet core to form a film capable of expanding and maintaining its physical integrity in the gastric milleu. - View Dependent Claims (2, 3, 4, 5)
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6. A gastric retention system in the form of a coated tablet comprising:
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(a) a core in the form of a tablet comprising an agent capable of generating internal pressure on the coat, and (b) a second coating formed by applying a coating composition comprising a film-forming polymer and one or more expandable components on the first coating whereby the second coating forms a film capable of expanding and maintaining its physical integrity in the gastric milleu. - View Dependent Claims (7)
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8. A gastric retention system in the form of a coated capsule, comprising:
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(a) a core in the form of a capsule, the core comprising an agent capable of generating internal pressure on the coating, and (b) an expandable coating formed by applying a coating composition comprising a film-forming polymer and one or more expandable components on the capsule core to form a film capable of expanding and maintaining its physical integrity in the gastric milleu. - View Dependent Claims (9, 10, 11, 12)
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13. (canceled)
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14. (canceled)
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15. A process for coating a tablet or capsule core comprising applying a coating composition comprising expandable components in a dry powder form or suspended in a non-solvent vehicle.
Specification