NANOPARTICULATE COMPOSITIONS OF ANGIOGENESIS INHIBITORS
First Claim
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1. A method of making an angiogenesis inhibitor composition comprising contacting particles of at least one angiogenesis inhibitor or a salt thereof with at least one surface stabilizer for a time and under conditions sufficient to provide an angiogenesis inhibitor composition having an effective average particle size of less than about 2 microns, wherein the resultant composition comprises:
- (a) particles of an angiogenesis inhibitor or a salt thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer.
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Abstract
Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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22 Claims
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1. A method of making an angiogenesis inhibitor composition comprising contacting particles of at least one angiogenesis inhibitor or a salt thereof with at least one surface stabilizer for a time and under conditions sufficient to provide an angiogenesis inhibitor composition having an effective average particle size of less than about 2 microns, wherein the resultant composition comprises:
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(a) particles of an angiogenesis inhibitor or a salt thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification