Pain relief composition

• US 20080107747A1
• Filed: 12/18/2007
• Published: 05/08/2008
• Est. Priority Date: 10/23/2006
• Status: Abandoned Application

• Current Assignee: Guthy-Renker Corporation (Guthy-Renker Partners, Inc.)
• Original Assignee: Guthy-Renker Corporation (Guthy-Renker Partners, Inc.)
• Inventors: Roederer, Joy
• Application Number:
  US12/004,336
• Publication Number:
  US 20080107747A1
• Time in Patent Office: Days
• US Class Current: 424/490
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/704 Polygonum, e.g. knotweed
• CPC Class Codes: A61K 36/71 Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
• CPC Class Codes: A61K 36/886 Aloeaceae (Aloe family), e.g. aloe vera
• CPC Class Codes: A61K 36/9068 Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/127 Liposomes

Abstract

Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the following: an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles; an effective amount of a cooling component; an effective amount of a heat minimizing or blocking component; an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves; and an effective amount of a soothing and anti-inflammatory complex for the joints and/or muscles comprising Glucosamine sulfate or HCl, Zingiber officiniale (Ginger Root) extract, Methyl sulfonylmethane (MSM), Polygonum cuspidatum (Mexican Bamboo) extract, Aloe barbadensis leaf, and Salix alba (white willow) bark extract. Additionally, the composition includes an encapsulation or entrapment system for a timed release delivery.

Claims

1. A topical pain relief composition comprising:

an effective amount of a pain relieving component, including capsaicin, a capsaicinoid, a capsaicin analogue, or combinations thereof, wherein said pain relieving component is present in an amount of up to 0.75% by weight of total composition;

an effective amount of an inflammation control component comprising at least one agent selected from the group comprising linoleic acid, ginger root extract, willow bark, polygonum cuspidatum extract, aloe vera, oleic acid, coriander oil, MSM, glucosamine, and willow herb;

an effective amount of a cooling component, wherein said cooling component is selected from the group comprising menthyl lactate, ethyl menthane carboxamide, and methyl diisopropyl propionamide, menthone glycerin acetal, or a combination thereof;

an effective amount of a heat absorbing component, wherein said heat absorbing component includes zanthoxylum alatum extract;

an effective amount of a circulation increasing component comprising gynostemma pentaphyllum extract and ginseng extract; and

an effective amount of a soothing and anti-inflammatory complex comprising a combination of two or more agents selected from the group comprising glucosamine or a salt thereof, ginger root extract, methyl sulfonylmethane (MSM), polygonum cuspidatum extract, aloe barbadensis leaf, and salix alba (white willow) bark extract.

2. A topical pain relief composition comprising:

an effective amount of a pain relieving component, including capsaicin, a capsaicinoid, a capsaicin analogue, or combinations thereof;

an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles;

an effective amount of a cooling component;

an effective amount of a heat absorbing component;

an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves; and

an effective amount of a soothing and anti-inflammatory complex for the joints and/or muscles comprising glucosamine, zingiber officiniale (ginger root) extract, methyl sulfonylmethane (MSM), polygonum cuspidatum (Mexican bamboo) extract, aloe barbadensis leaf, and salix alba (white willow) bark extract.

3. The composition of claim 2 wherein said pain relieving component is present in an amount of up to 0.75% by weight of total composition.

4. The composition of claim 2 wherein said cooling component comprises:

approximately between 0.5-20% of a mixture containing menthyl lactate, ethyl menthane carboxamide, and methyl diisopropyl propionamide, and

approximately between 0.1-10% of menthone glycerin acetal.

5. The composition of claim 2 wherein said heat absorbing component includes zanthoxylum alatum extract.

6. The composition of claim 2 wherein said circulation increasing component includes gynostemma pentaphyllum extract and ginseng.

7. A topical pain relief composition comprising:

an effective amount of a pain relieving component comprising capsaicin a capsaicinoid, a capsaicin analogue, or combinations thereof;

at least six additional actives selected from the group comprising willow bark extract, ginger extract, willow herb extract, aloe vera extract, glucosamine or a salt thereof, MSM, gynostemma pentaphyllum extract, panax ginseng extract, zanthoxyllum alatum extract, and polygonum cuspidatum extract, and combinations thereof.

8. The composition of claim 7, further comprising an effective amount of a cooling component selected from the group comprising effective menthyl lactate, ethyl menthane carboxamide, methyl diisopropyl propionamide, menthone glycerin acetal.

9. The composition of claim 8, wherein said cooling component includes:

menthyl lactate, ethyl menthane carboxamide, and methyl diisopropyl propionamide, encapsulated in nanospheres, said nanoshpheres having an average particle size of approximately between 0.01 and 1 microns; and

menthone glycerin acetal.

10. A pain relief composition comprising as active components:

capsaicin, in an amount of up to 0.75%;

willow bark extract;

ginger extract;

willow herb extract;

aloe vera extract;

glucosamine;

MSM;

gynostemma pentaphyllum;

ginseng; and

polygonum cuspidatum.

11. The composition of claim 10, further comprising linoleic acid, zanthoxylum alatum, oleic acid, cooling agents, and coriander seed oil.