Ramipril formulation
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Abstract
A Ramipril formulation which is suitably stabilised to control the degradation to the active metabolite ramiprilat.
51 Citations
43 Claims
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1-9. -9. (canceled)
- 10. A method of making a ramipril formulation, comprising obtaining a ramipril salt by wet granulation of ramipril in the presence of alkali and incorporating the ramipril salt into the formulation, wherein at least 50% by weight of the ramipril in the formulation is in the form of a ramipril salt and wherein the formulation comprises a pharmaceutical carrier.
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33-34. -34. (canceled)
- 35. A method of making a ramipril formulation, comprising obtaining a ramipril-containing preparation and incorporating said preparation into said formulation, wherein at least 50% by weight of the ramipril in the ramipril-containing preparation is in the form of a ramipril salt.
Specification