Predicting patient compliance with medical treatment

• US 20080109252A1
• Filed: 11/08/2006
• Published: 05/08/2008
• Est. Priority Date: 11/08/2006
• Status: Abandoned Application

• Current Assignee: Astrazeneca AB (Astrazeneca PLC)
• Original Assignee: Astrazeneca AB (Astrazeneca PLC)
• Inventors: Casten, Kircia, LaFountain, Andrea, Taylor, Brooke S.
• Application Number:
  US11/595,169
• Publication Number:
  US 20080109252A1
• Time in Patent Office: Days
• US Class Current: 705/2
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients

Abstract

Methods for predicting a patient'"'"'s adherence to a medical treatment and optimizing the patient'"'"'s treatment are provided. A questionnaire is developed using statistical analysis and/or mathematical modeling of factors affecting patient adherence, and is administered to a patient. Such factors may include the patient'"'"'s openness to being persuaded to adhere to the medical regimen, the patient'"'"'s perception of the risks and benefits associated with the medical regimen, and/or other patient-related factors. Based on the patient'"'"'s answers to the questionnaire, a degree of adherence to the medical regimen associated with the patient is predicted and an intervention program is recommended to improve the patient'"'"'s compliance with the treatment plan in the regimen.

Claims

1. A method for predicting a patient'"'"'s adherence to a medical regimen, the method comprising:

administering a plurality of questions to the patient, the questions relating to at least one of;

(1) the patient'"'"'s openness to being persuaded to adhere to the medical regimen, and (2) the patient'"'"'s perception of the risks and benefits associated with the medical regimen; and

determining a degree of adherence to the medical regimen associated with the patient based on the patient'"'"'s answers to the questions.

2. The method of claim 1 wherein at least one the questions relates to the patient'"'"'s psychological states and traits.

3. The method of claim 1 wherein:

each of the plurality of questions is in the form of a statement in which the patient is asked to rate a degree to which the patient agrees with the statement; and

the degree of adherence to the medical regimen is associated with a score calculated from summing each rating.

4. A method for optimizing a patient'"'"'s medical treatment, the method comprising:

administering a plurality of questions to the patient, the questions relating to at least one of;

(1) the patient'"'"'s openness to being persuaded to adhere to a medical regimen, and (2) the patient'"'"'s perception of the risks and benefits associated with the medical regimen;

predicting the patient'"'"'s adherence to the medical regimen based on the patient'"'"'s answers to the questions; and

recommending an intervention program for the patient based on the predicted adherence.

5. The method of claim 4 wherein each one of the plurality of questions is in the form of a statement in which the patient is asked to rate a degree to which the patient agrees with the statement.

6. The method of claim 5 wherein the degree of adherence to the medical regimen is associated with a score calculated from summing each rating.

7. The method of claim 6 wherein the recommended intervention program is based on the calculated score.

8. The method of claim 6 wherein no intervention program is recommended when the score associated with the degree of adherence is higher than a predetermined threshold.

9. The method of claim 5 wherein:

a first score is calculated from summing each rating of the degree to which the patient agrees with the statements relating to the patient'"'"'s openness to being persuaded to adhere to the medical regimen; and

a second score is calculated from summing each rating of the degree to which the patient agrees with the statements relating to the patient'"'"'s perception of the risks and benefits associated with the medical regimen.

10. The method of claim 9 wherein the recommended intervention program is based on the first and second scores.

11. A method for developing a questionnaire for use in predicting a patient'"'"'s adherence to a medical regimen, the method comprising:

identifying measures that display adequate psychometric properties with respect to factors affecting patient adherence;

conducting a survey of a group of patients by administering to the patients a plurality of questions that are based on the identified measures;

analyzing the results from the conducted survey to determine key factors that are predictive of intention to persist with medical treatment; and

deriving a questionnaire based on at least a subset of the key factors.

12. The method of claim 11 wherein the identified measures comprise at least one measure that is selected from the group consisting of Multidimensional Health Locus of Control Scale, Strategies Used by Patients to Promote Health, SF-12 Life Orientation Test-Revised, Beck Depression Inventory-II, State Trait Anxiety Inventory, and Healthcare System Distrust Scale.

13. The method of claim 11 wherein the identified measures comprise at least one measure that is developed for the purpose of conducting the survey.

14. The method of claim 13 wherein the at least one measure is developed to assess beliefs, attitudes, and social support.

15. The method of claim 13 wherein the at least one measure is developed to assess intention to persist.

16. The method of claim 11 wherein the analyzing the results from the conducted survey comprises applying at least one of factor analysis, cluster analysis, and cluster partitioning.

17. The method of claim 11 wherein the analyzing the results from the conducted survey comprises applying at least one of univariate logistic and partial least square regressions, principal component analysis, and structural equation modelling.

18. The method of claim 11 wherein the deriving the questionnaire is further based on retaining factors that may be ethically influenced in a patient.

19. The method of claim 11 wherein the deriving the questionnaire is further based on retaining factors that may be substantially influenced in a patient.

20. The method of claim 11 wherein the derived questionnaire is based on patient openness to being persuaded to adhere to the medical regiment and patient perception of the risks and benefits associated with the medical regimen.