CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM
First Claim
1. A drug delivery system, comprising:
- an aerosol generator unit wherein a liquid formulation is partially vaporized to form an aerosol;
a pumping unit adapted to supply a liquid formulation to the aerosol generator unit;
a flow passage having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface which supplies ventilation to a patient'"'"'s lungs;
at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit; and
an aerosol transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.
1 Assignment
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Accused Products
Abstract
A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially vaporized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation to a patient'"'"'s lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.
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Citations
63 Claims
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1. A drug delivery system, comprising:
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an aerosol generator unit wherein a liquid formulation is partially vaporized to form an aerosol; a pumping unit adapted to supply a liquid formulation to the aerosol generator unit; a flow passage having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface which supplies ventilation to a patient'"'"'s lungs; at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit; and an aerosol transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 18, 19, 20, 21)
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12-17. -17. (canceled)
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22. (canceled)
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23. A disposable assembly operable to produce an aerosol, the disposable assembly comprising:
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a capillary tube adapted to form an aerosol when a liquid formulation in the capillary tube is heated to volatilize at least some of the liquid material therein; a syringe assembly comprised of at least one syringe and a plurality of valves operable to supply the liquid formulation into an inlet of the capillary tube; a sheath air passage operable to receive a ventilated or hospital air supply; and an aerosol transition adapter arranged to mix aerosol produced by the capillary tube with heated air from the sheath air tube and directs the mixed aerosol into the inlet end of a flow passage. - View Dependent Claims (24, 25, 26)
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27. A base unit adapted to receive a disposable assembly having an aerosol generator unit therein, the base unit comprising:
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a disposable assembly housing adapted to receive the disposable assembly; a syringe pump operable to supply a liquid formulation to the aerosol generator unit; and a control system operable to activate the aerosol generator unit and the syringe pump, such that the liquid formulation is partially vaporized to form an aerosol. - View Dependent Claims (28)
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29. (canceled)
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30. An apparatus to produce an aerosol comprising:
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a heated capillary aerosol generator; an arrangement to produce a flow of heated air; and a mixer to mix the flow of heated air with an output of the heated capillary aerosol generator.
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31. A method of producing an aerosol comprising:
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generating an aerosol with a heated capillary; and admixing heated air with the generated aerosol so as to reduce condensation. - View Dependent Claims (32, 33, 63)
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34-61. -61. (canceled)
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62. An aerosol generator capable of delivering an aerosol with a drug concentration of 2.3 milligrams per liter of air from a liquid formulation with a drug concentration of 10 milligrams per milliliter (mg/ml) and commensurately higher aerosol concentrations from formulations with higher concentrations.
Specification