ENGINEERING SHAPE OF POLYMERIC MICRO- AND NANOPARTICLES
First Claim
1. A method of making non-spherical particles comprisingproviding polymeric nano or micro particles in a polymeric film and applying physical manipulation of the polymeric film to change the shape of the particles.
3 Assignments
0 Petitions
Accused Products
Abstract
Compositions containing polymeric micro- and nanoparticles with non-spherical shapes and methods for making and using such particles are described herein. The particles have a size range from an average diameter of about Compositions containing polymeric micro- and nanoparticles with non-spherical shapes and methods for making and using such particles are described herein. The particles have one or more dimensions ranging from about 5 nm to about 100 μm, preferably about 100 nm to 10 μm. The particles can have any of a wide variety of non-spherical shapes. The particles are generally formed by manipulation of spherical particles embedded in a polymeric film. A wide variety of resulting shapes can be made. The resulting shape is a function of whether the films are manipulated in a first and/or second dimension, and the processes used to liquefy the microparticles. Variations of the method of manufacture may be used to generate particles having the desired shapes in large, reproducible quantities. The resulting non-spherical shaped particles can be used to alter uptake by phagocytic cells and thereby clearance by the reticuloendothelial system.
-
Citations
16 Claims
-
1. A method of making non-spherical particles comprising
providing polymeric nano or micro particles in a polymeric film and applying physical manipulation of the polymeric film to change the shape of the particles.
- 8. A polymeric film comprising non-spherical nano or micro particles, wherein the polymeric film comprises a different polymer than the nano or micro particles.
-
10. Non-spherical nano or micro particles prepared by a method comprising
providing spherical nano or micro particles in a polymeric film and applying physical manipulation of the polymeric film to change the shape of the particles.
- 13. A method of treating an organism by administering at least one therapeutic agent encapsulated in at least one non-spherical nano or micro particle.
-
16. A method of diagnosing an organism by administering at least one diagnostic agent encapsulated in at least one non-spherical nano or microparticle.
Specification