Bone cell delivery device

• US 20080112996A1
• Filed: 10/02/2007
• Published: 05/15/2008
• Est. Priority Date: 12/14/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Langer, Robert, Harlow, Ed, Jung, Edward, Leuthardt, Eric, Hyde, Roderick, Wood, Lowell
• Granted Patent: US 9,005,943 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61F 2/00 Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents as cosmetic articles, see the relevant subclasses, e.g. wigs, hair pieces, A41G3/00, A41G5/00; artificial nails A45D31/00; dental prostheses A61C13/00; materials for prostheses A61L27/00; artificial hearts A61M60/00; artificial kidneys A61M1/14
• CPC Class Codes: A61K 2035/126 Immunoprotecting barriers, e.g. jackets, diffusion chambers
• CPC Class Codes: A61K 47/6901 Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3808 Endothelial cells
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C12N 2510/00 Genetically modified cells
• CPC Class Codes: C12N 5/0654 Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth

Abstract

Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.

Claims

1-178. -178. (canceled)

179. A method for delivering one or more biologically active molecules to a subject, comprising:

identifying the one or more biologically active molecules, and

implanting in the subject one or more devices constructed of bone cells and configured to at least partially form an internal cavity, wherein the one or more biologically active molecules are included in the one or more devices.

182. The method of claim 179, further comprising:

providing the one or more biologically active molecules to the internal cavity.

183. The method of claim 182, wherein providing the one or more biologically active molecules to the internal cavity comprises:

providing the one or more biologically active molecules to the internal cavity following implantation of the one or more devices into the subject.

184. The method of claim 182, wherein providing the one or more biologically active molecules to the internal cavity comprises:

providing the one or more biologically active molecules to the internal cavity before implantation of the one or more devices into the subject.

185. The method of claim 182, wherein providing the one or more biologically active molecules to the internal cavity comprises:

providing one or more living cells or tissues to the internal cavity, wherein the one or more living cells or tissues release the one or more biologically active molecules.

186. The method of claim 179, further comprising:

identifying one or more living cells or tissues to release the one or more biologically active molecules; and

providing the one or more living cells or tissues to the internal cavity.

187. The method of claim 186, wherein the one or more living cells or tissues are engineered to release the one or more biologically active molecules.

188. The method of claim 179, wherein the bone cells include viable bone cells cultured in vitro from stem cells.

189. The method of claim 188, wherein the stem cells are autonomous with respect to the subject.

190. The method of claim 188, wherein the stem cells are allogeneic with respect to the subject.

191. The method of claim 188, wherein the stem cells are xenogeneic with respect to the subject.

192. The method of claim 179, further comprising:

selecting the one or more devices constructed of bone cells having a semi-permeable component lining the internal cavity.

193. The method of claim 192, further comprising:

providing the one or more biologically active molecules to the internal cavity.

194. The method of claim 179, further comprising:

selecting one or more semi-permeable components; and

providing the one or more semi-permeable components to the internal cavity of the one or more devices.

195. The method of claim 179, wherein the one or more devices constructed of bone cells include one or more semi-permeable components.

196. The method of claim 179, further comprising:

selecting one or more semi-permeable components; and

surrounding the bone cells with the one or more semi-permeable components.

197. The method of claim 179, wherein the one or more devices constructed of bone cells include one or more closable openings.

198. The method of claim 197, further comprising:

providing the one or more biologically active molecules to the internal cavity through one or more of the one or more closable openings.

199. The method of claim 198, providing the one or more biologically active molecules to the internal cavity through one or more of the one or more closable openings comprises:

providing the one or more biologically active molecules to the internal cavity through one or more of the one or more closable openings following implantation in the subject.

200. The method of claim 197, further comprising:

closing the one or more closable openings.

201. The method of claim 179, wherein the subject is an animal.

202. The method of claim 201, wherein the animal is selected from the group consisting of a domesticated animal, a farm animal, a marine animal, a sport animal, a wild animal, a research animal, a zoo animal, a bird, an amphibian, a reptile, a fish, and a mammal.

203. The method of claim 202, wherein the mammal is a human.

180-181. -181. (canceled)

204. A method for delivering one or more biologically active molecules to a subject, comprising:

identifying the one or more biologically active molecules,

identifying one or more living cells or tissues to release the one or more biologically active molecules;

selecting one or more implantable structures constructed of bone cells configured to at least partially form an internal cavity, wherein the internal cavity is lined with a semi-permeable component;

implanting one or more devices into the subject; and

providing the one or more living cells or tissues engineered to release the one or more biologically active molecules to the internal cavity of the one or more devices.

205. A method for delivering one or more biologically active molecules to a subject, comprising:

identifying the one or more biologically active molecules,

identifying one or more living cells or tissues to release the one or more biologically active molecules;

selecting one or more implantable structures constructed of bone cells configured to at least partially form an internal cavity and having one or more closable openings, wherein the internal cavity is lined with a semi-permeable component;

providing the one or more living cells or tissues engineered to release the one or more biologically active molecules to the internal cavity of the one or more devices through one or more of the closable openings;

closing the one or more closable openings; and

implanting one or more devices into the subject.