Marker Gene for Arthrorheumatism Test
First Claim
1. A marker gene for rheumatoid arthritis test consisting of a consecutive partial DNA sequence comprising at least one base exhibiting single nucleotide polymorphism present in a TNXB, NOTCH4, RAB6A, MPRL48, UCP2 or UCP3 gene in the human genomic DNA sequence, or of a complementary strand of the partial DNA sequence.
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Abstract
It is intended to identify rheumatoid arthritis susceptibility genes by a highly efficient, low-cost mapping method using microsatellites. In the present invention, novel rheumatoid arthritis susceptibility genes, that is, TNXB, NOTCH4, RAB6A, MPRL48, UCP2, and UCP3 genes, in the human genomic DNA sequence were identified by conducting case-control association analysis on rheumatoid arthritis by use of microsatellite polymorphic markers assigned at approximately 100-kb intervals to narrow down candidate regions and then conducting association analysis and linkage analysis with SNP as a marker.
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Citations
14 Claims
- 1. A marker gene for rheumatoid arthritis test consisting of a consecutive partial DNA sequence comprising at least one base exhibiting single nucleotide polymorphism present in a TNXB, NOTCH4, RAB6A, MPRL48, UCP2 or UCP3 gene in the human genomic DNA sequence, or of a complementary strand of the partial DNA sequence.
Specification