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Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same

  • US 20080113351A1
  • Filed: 11/13/2006
  • Published: 05/15/2008
  • Est. Priority Date: 05/11/2004
  • Status: Abandoned Application
First Claim
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1. A polynucleotide for causing RNA interference against a target gene selected from the genes of a target organism, which has at least a double-stranded region, wherein one strand in the double-stranded region consists of a base sequence homologous to a prescribed sequence which is contained in the base sequences of the target gene and which conforms to the following rules (a) to (d):

  • (a) The 3′

    end base is adenine, thymine or uracil;

    (b) The 5′

    end base is guanine or cytosine;

    (c) A 7-base sequence from the 3′

    end is rich in one or more types of bases selected from the group consisting of adenine, thymine and uracil; and

    (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity, andwherein the other strand in the double-stranded region consists of a base sequence having a sequence complementary to the base sequence homologous to the prescribed sequence.

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