Antimicrobial wash formulations including amidoamine-based cationic surfactants

• US 20080113892A1
• Filed: 11/10/2006
• Published: 05/15/2008
• Est. Priority Date: 11/10/2006
• Status: Active Grant

• Current Assignee: GOJO Industries Incorporated
• Original Assignee: GOJO Industries Incorporated
• Inventors: Barnhart, Ronald A., Lerner, David P.
• Granted Patent: US 7,517,842 B2
• Time in Patent Office: Days
• US Class Current: 510/138
• CPC Class Codes: C11D 1/528 Carboxylic amides (R1-CO-NR2R3), where at least one of the chains R1, R2 or R3 is interrupted by a functional group, e.g. a -NH-, -NR-, -CO-, or -CON- group ethers C11D1/526
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

An antimicrobial hand wash comprises an active ingredient and an amidoamine based cationic surfactant having a fatty chain with from 6 to 24 carbon atoms. These cationic surfactants are compatible with common active ingredients such that antimicrobial efficacy is maintained, while foam quality is improved when the hand wash is dispensed as foam. Other antimicrobial hand washes include specific amidoamine based cationic surfactants that dissolve at least a portion of the active ingredient, thus reducing the amount of solids in the formulation, and, in some instances, making a cold manufacturing process possible.

Claims

1. An antimicrobial hand wash comprising:

an active ingredient and a cationic surfactant produced from the neutralization of an amidoamine with an acid, wherein the amidoamine is selected to have a primary fatty chain with from 6 to 24 carbon atoms.

2. The hand wash of claim 1, wherein said active ingredient is selected from the group consisting of bisguanidines, diphenyl compounds, quaternary ammonium compounds, benzyl alcohols, trihalocarbanilides, ethoxylated phenols, iodine and iodine containing compounds and phenolic compounds, and mixtures of the foregoing.

3. The hand wash of claim 2, wherein said active ingredient is a phenolic compound selected from the following:

(a) 2-hydroxydiphenyl compounds according to the following formula

4. The hand wash of claim 1, wherein the amidoamine is selected from almondamidopropyl dimethylamine, avacadamidopropyl dimethylamine, babassuamidopropyl dimethylamine, behenamidopropyl dimethylamine, cocamidopropyl dimethylamine, cocamidopropyl morpholine, hydroxyethyl carboxymethyl cocamidopropyl amine, isostearamidopropyl dimethylamine, isostearamidopropyl morpholine, laurmidopropyl dimethylamine, linoleamidopropyl dimethylamine, oatamidopropyl dimethylamine, oleamidopropyl dimethylamine, olivamidopropyl dimethylamine, palmitamidopropyl diethylamine, palmitamidopropyl dimethylamine, ricinoleamidopropyl dimethylamine, sesamidopropyl dimethylamine, ricinoleamidopropyl dimethylamine, soyamidopropyl dimethylamine, stearamidoethyl dimethanolamine, stearamidoethyl diethylamine, stearamidopropyl ethanolamine, stearamidpropyl dimethylamine, stearamidopropyl morpholine, sunflowerseedamidopropyl dimethylamine, tallamidopropyl dimethylamine, tallowamidopropyl dimethylamine, wheat geramidopropyl dimethylamine, and mixtures of the forgoing.

5. The hand wash of claim 4, wherein the amidoamine is neutralized with an acid selected from the group consisting of carboxylic acids, organic acid anhydrides, mixed acid anhydrides, polyprotic acids, monoprotic acids, inorganic acid anhydrides, and mixtures of the forgoing.

6. The hand wash of claim 5, wherein the cationic surfactant is selected from the group consisting of behenamidopropyl dimethylamine behenate, behenamidopropyl dimethylamine lactate, cocamidopropyl dimethylamine dihydroxymethylpropionate, coamidopropyl dimethylamine lactate, cocamidopropyl dimethylamine propionate, coamidopropyl morpholine lactate, isostearamidopropl dimethylamine gluconate, isostearamidopropyl dimethylaimin glycolate, isostearamidpropyl dimethylamine lactate, lauramidopropyl dimethylamine propionate, linoleamidopropyl dimethylaimine dimmer dilinoleate, oleamidopropyl dimethylaimine glycolate, oleamidopropyl dimethylamine lactate, olemidopropyl dimethylamine propionate, olivamidopropyl dimethylamine lactate, palmitamidopropyl dimethylamine lactate, palmitamidopropyl dimethylamine propionate, palmitoleamidopropyl dimethylamine lactate, palmitoleamidopropyl dimethylamine propionate, ricinoleamidopropyl dimethylamine lactate, stearamidoethyl diethylamine phosphate, stearamidoethyl ethanolamine phosphate, stearamidopropyl dimethylamine lactate, stearamidopropyl dimethylamine stearate, sunflowerseedamidopropyl dimethylamine lactate, sunflowerseedamidopropyl dimethylamine malate, sunflowerseedamidopropyl morpholine lactate, wheat germamidopropyl dimethylamine lactate, decarboxy camosine HCl, stearamidopropyl morpholine lactate, and mixtures of the forgoing.

7. The hand wash of claim 3, wherein the cationic surfactant is selected from the group consisting of lauramidopropyl dimethylamine, cocamidopropyl dimethylamine, and ricinoleamidopropyl dimethylamine neutralized with an acid selected from the group consisting of citric acid, glutaric acid, oxalic acid, sulfuric acid, hydrochloric acid, glycolic acid, malic acid, itaconic acid, nicotinic acid, benzoic acid, acetylsalicylic acid, serine, boric acid, formic acid, propionic acid, succinic acid, adipic acid, lactic acid, and mixture of the forgoing.

8. The hand wash of claim 7, wherein the active ingredient is selected from the group consisting of 2,3,4′

-trichloro-2′

-hydroxydiphenylether, parachlorometaxylenol and mixtures thereof.

9. The hand wash of claim 8, wherein the active ingredient is 2,3,4′

-trichloro-2′

-hydroxydiphenylether, and the cationic surfactant is lauramidopropyl dimethylamine lactate.

10. The hand wash of claim 1, comprised of from about 0.01 to 10 weight percent (wt %) of active ingredient.

11. The hand wash of claim 10, comprised of from about 0.1 to 20 wt % of said cationic surfactant.

12. The hand wash of claim 11, comprised of from 0.5 to 7.5 wt % of said cationic surfactant.

13. The hand wash of claim 1, having a maximum percent of solids of less than 15 wt %.

14. A method for forming a hand wash comprising the steps of:

creating an active ingredient premix by mixing a phenolic compound active ingredient with a cationic surfactant produced from the neutralization of an amidoamine with an acid, wherein the amidoamine is selected to have a primary fatty chain with from 6 to 24 carbon atoms, said mixing affecting at least a partial dissolving of the phenolic compound without the need for the addition of heat to dissolve the same; and

mixing said active ingredient premix with water.