Biomedical Compositions

• US 20080114090A1
• Filed: 01/24/2008
• Published: 05/15/2008
• Est. Priority Date: 08/02/1999
• Status: Active Grant

• Current Assignee: Anthony Clayton, Gordon Meijs
• Original Assignee: Anthony Clayton, Gordon Meijs
• Inventors: Meijs, Gordon, Clayton, Anthony
• Granted Patent: US 7,556,822 B2
• Time in Patent Office: Days
• US Class Current: 522/99
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08G 77/38 Polysiloxanes modified by chemical after-treatment C08G77/045 takes precedence
• CPC Class Codes: C08G 77/388 containing nitrogen
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of Formula I: The macromonomer is then polymerised to give a polymer suitable for use in an intraocular lens.

Claims

1-39. -39. (canceled)

40. An ethylenically unsaturated macromonomer comprising a random or block copolymer of Formula I:

41. An ethylenically unsaturated macromonomer according to claim 40 in which the ratio of x:

y is between about 100;

1 and about 200;

1.

42. An ethylenically unsaturated macromonomer according to claim 40 wherein the molecular weight of the macromonomer is in the range 3,000-80,000.

43. An ethylenically unsaturated macromonomer according to claim 40 in which -L-Z is an aminoalkyl or hydroxyalkyl group functionalized with (meth)acrylate or (meth)acrylamide.

44. An ethylenically unsaturated macromonomer according to claim 40 wherein the macromonomer is prepared by reacting a mixture comprising polydimethyl-aminopropylsiloxane co-polymer and 2-vinyl-4,4-dimethylazlactone.

45. An ethylenically unsaturated macromonomer according to claim 40 wherein the macromonomer has a viscosity at 25°

C. in the range 1,000-20,000 cSt.

46. An ethylenically unsaturated macromonomer according to claim 40 wherein the macromonomer has a viscosity at 25°

C. in the range 1,000-10,000 cSt.

47. An ethylenically unsaturated macromonomer according to claim 40 wherein the polymer has a modulus within a range of 0.1-10 kPa.

48. An ethylenically unsaturated macromonomer according to claim 40 wherein the polymer has a modulus within a range of 0.5-5 kPa.

49. An ethylenically unsaturated macromonomer according to claim 40 wherein the polymer has a modulus within a range of 0.1-5 kPa.

50. An ethylenically unsaturated macromonomer according to claim 40 wherein after polymerization the polymer has a refractive index in the range 1.39-1.44.

53. A method of preparing intraocular lenses in situ by injecting a flowable macromonomer according to claim 40 into a lens capsular bag and polymerizing the macromonomer to provide a polymer, wherein the macromonomer has a viscosity at 25°

C. in the range 1,000-20,000 cSt.

54. A method of treating presbyopia by removing the lens material and injecting a flowable macromonomer according to claim 40 into a lens capsular bag and polymerizing the macromonomer to provide a polymer, wherein the macromonomer has a viscosity at 25°

C. in the range 1,000-20,000 cSt.

56. A method according to claim 53 further comprising adding a photoinitiator.

57. A method according to claim 56 in which the amount of photoinitiator is between 0.05% and 2% by weight.

58. A polymer comprising macromonomers according to claim 40.

60. A polymer according to claim 58 in which the macromonomers comprise at least 50% by weight.

62. A polymer according to claim 58 in which the macromonomers comprise at least 80% by weight.

63. A polymer according to claim 60 further comprising other macromonomers to adjust the refractive index of the polymer.

64. A polymer according to claim 60 further comprising other macromonomers to adjust the viscosity of the polymer.

65. An intraocular lens comprising a polymer according to claim 60.

51. An ethylenically unsaturated macromonomer comprising a random or block copolymer of Formula I:

52. An ethylenically unsaturated macromonomer according to claim 51 in which -L-Z is an aminoalkyl or hydroxyalkyl group functionalized with (meth)acrylate or (meth)acrylamide.

55. A method of treating presbyopia by removing the lens material and injecting a flowable macromonomer according to claim 51 into a lens capsular bag and polymerizing the macromonomer to provide a polymer, wherein the macromonomer has a viscosity at 25°

C. in the range 1,000-20,000 cSt.

59. A polymer comprising macromonomers according to claim 51.

61. A polymer according to claim 59 in which the macromonomers comprise at least 50% by weight.

66. An intraocular lens comprising a polymer according to claim 61.