TRANSDERMAL DRUG DELIVERY SYSTEMS, DEVICES, AND METHODS USING INDUCTIVE POWER SUPPLIES

• US 20080114282A1
• Filed: 09/05/2007
• Published: 05/15/2008
• Est. Priority Date: 09/05/2006
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcu Ltd.
• Inventors: Carter, Darrick
• Application Number:
  US11/850,600
• Publication Number:
  US 20080114282A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

An iontophoresis device for providing transdermal delivery of one or more therapeutic active agents to a biological interface having an active electrode assembly, a counter electrode assembly, and an inductor electrically coupled to the active and the counter electrode assemblies. The inductor is operable to provide a voltage across at the active and the counter electrode elements in response to an applied varying electromagnetic field.

Claims

1. A system for delivering one or more active agents to a biological entity under the influence of an inductive power supply, comprising:

an inductive power supply including a primary winding operable to produce a varying magnetic field; and

an iontophoresis device including at least one active agent reservoir to store the one or more active agents, an active electrode element operable to apply an electromotive force to the active agent reservoir, a counter electrode element, and a secondary winding electrically coupled to the active and the counter electrode elements for providing a voltage across the active and counter electrode elements in response to the varying magnetic field of the inductive power supply;

wherein the iontophoresis device is physically distinct from the inductive power supply.

2. The system of claim 1 wherein the inductive power supply is operable to provide at least one of an alternating current or a pulsed direct current to the primary winding.

3. The system of claim 1 wherein the iontophoresis device includes a rechargeable power source electrically coupled to the active and counter electrode elements, and electrically coupled in parallel with the secondary winding to receive a charge thereby.

4. The system of claim 3 wherein the rechargeable power source sinks and sources voltage to maintain a steady state operation of the iontophoresis device.

6. The system of claim 1 wherein the inductive power supply is operable to manage a duty cycle associated with delivering a therapeutically effective amount of the one or more active agents.

7. The system of claim 1 wherein the inductive power supply is operable to provide at least one of an alternating current or a pulsed direct current to the primary winding with a duty cycle based on a delivery profile defined for at least one of the one or more active agents or the biological entity.

8. A method of powering an iontophoretic delivery device, the method comprising:

varying a current applied to a primary winding housed separately form the iontophoretic delivery device to generate a varying electromagnetic field; and

positioning a secondary winding housed by the iontophoretic delivery device such that the secondary winding will be within the varying magnetic field when generated.

9. The method of claim 8, further comprising:

positioning an active electrode and a counter electrode of the iontophoretic delivery device on a biological subject.

10. The method of claim 8, further comprising:

positioning an active electrode and a counter electrode of the iontophoretic delivery device on a biological subject before varying the current applied to the primary winding to generate the varying electromagnetic field such that active agent is supplied to the biological entity in response to varying the current.

11. The method of claim 8 wherein varying the current applied to the primary winding includes varying the current according to a delivery profile.

12. The method of claim 8 wherein varying the current applied to the primary winding includes varying the current according to a delivery profile based on the active agent.

13. The method of claim 8 wherein varying the current applied to the primary winding includes varying the current according to a delivery profile based on at least one parameter indicative of a physical feature of the biological subject.

14. The method of claim 8, further comprising:

storing power to a rechargeable power supply.

15. The method of claim 8, further comprising:

positioning an active electrode and a counter electrode of the iontophoretic delivery device on a biological subject after storing power to the rechargeable power supply before varying the current applied to the primary winding to generate the varying electromagnetic field such that active agent is supplied to the biological entity in response to stored power.

16. A method of forming an inductively powered iontophoretic device, comprising:

forming an inductor element on at least a first substrate having a first surface and a second surface opposing the first surface; and

electrically coupling the inductor element to an iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly including at least one active agent reservoir and at least one active electrode element operable to provide an electromotive force to drive an active agent from the at least one active agent reservoir, the counter electrode assembly including at least one counter electrode element;

wherein the inductor element is operable to provide a voltage across at least the active and the counter electrode elements in response to a varying electromagnetic field applied to the inductor element from an external source.

5. The iontophoresis device of claim 16 wherein the rechargeable power source comprises at least one of a chemical battery cell, super- or ultra-capacitor, a fuel cell, a secondary cell, a thin film secondary cell, a button cell, a lithium ion cell, zinc air cell, and a nickel metal hydride cell.

17. The method of claim 16 wherein forming an inductor element on at least a first substrate includes depositing a conductive trace on at least the first surface of the first substrate;

wherein the conductive trace is operable to provide a voltage across at least the active and the counter electrode elements in response to a varying electromagnetic field applied to the conductive trace.

18. The method of claim 16 wherein forming an inductor element on at least a first substrate includes forming a first portion of the inductor element on the first substrate, and further comprising:

forming a second portion of the inductor element on a second substrate having a first surface and a second surface opposing the first surface.

19. The method of claim 16 wherein forming a first portion of the inductor element on the first substrate and forming a second portion of the inductor element on the second substrate comprises:

depositing a first conductive trace on the first surface of the first substrate;

depositing a second conductive trace on the first surface of the second substrate; and

forming a laminate comprising the first and the at least second substrates.

wherein the first and the second conductive traces are electrically coupled to form a multi-loop inductor, and the electrically coupled first and the second conductive traces are operable to provide a voltage across at least the active and the counter electrode elements in response to a varying electromagnetic field applied to the first and the second conductive traces.

20. The method of claim 16 wherein forming an inductor element on at least a first substrate comprises:

forming a photoresist mask for patterning the conductive trace on the first surface of the substrate; and

etching the conductive trace on the first surface of the substrate.

21. The method of claim 16, further comprising:

electrically coupling a rechargeable power supply in parallel with the inductor element, the rechargeable power supply operable to store power provided by the inductor element in response to an applied varying electromagnetic field.