Chromatography systems comprising single-use components

• US 20080116122A1
• Filed: 07/13/2007
• Published: 05/22/2008
• Est. Priority Date: 11/22/2006
• Status: Abandoned Application

• Current Assignee: Genitope Corp.
• Original Assignee: Genitope Corp.
• Inventors: Louie, Ed, Schamow, Steven, Wheelwright, Scott M., Zander, Andrew T.
• Application Number:
  US11/827,925
• Publication Number:
  US 20080116122A1
• Time in Patent Office: Days
• US Class Current: 210/87
• CPC Class Codes: B01D 15/10 characterised by constructional or operational features
• CPC Class Codes: G01N 30/88 Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86

Abstract

The present invention relates to single-use chromatography devices and systems for use with a durable component for processing compounds such as protein compounds.

Claims

1. A chromatography system comprising a durable component and a single-use component, wherein said durable component comprises a peristaltic pump and a pinch valve, and wherein said single-use component comprises a tubing harness comprising a plurality of reagent inlets, a fluid outlet, and a chromatography column.

2. The chromatography system of claim 1, wherein said tubing harness further comprises a pressure sensor.

3. The chromatography system of claim 1, wherein said tubing harness further comprises a pH sensor.

4. The chromatography system of claim 1, wherein said tubing harness further comprises a conductivity sensor.

5. The chromatography system of claim 1, wherein said tubing harness further comprises a detection flow cell.

6. The chromatography system of claim 5, wherein said detection flow cell comprises a UV detection flow cell.

7. The chromatography system of claim 1, wherein said durable component comprises a single peristaltic pump.

8. The chromatography system of claim 1, wherein said durable component further comprises a centralized control system.

9. The chromatography system of claim 8, wherein at least one pinch valve is controlled by said centralized control system.

10. The chromatography system of claim 8, wherein said peristaltic pump is controlled by said centralized control system.

11. The chromatography system of claim 1, wherein said durable component further comprises an optical detector.

12. The chromatography system of claim 11, wherein said optical detector detects in a light range comprising the UV range.

13. The chromatography system of claim 1, wherein said durable component further comprises a pH sensor.

14. The chromatography system of claim 1, wherein said durable component further comprises a conductivity sensor.

15. A single-use component for a chromatography system comprising a tubing harness, wherein said tubing harness comprises a plurality of reagent inlets, a fluid outlet, and a chromatography column.

16. The single-use component of claim 15, wherein said tubing harness further comprises a pressure sensor.

17. The single-use component of claim 15, wherein said tubing harness further comprises a pH sensor.

18. The single-use component of claim 15, wherein said tubing harness further comprises a conductivity sensor.

19. The single-use component of claim 15, wherein said tubing harness further comprises a detection flow cell.

20. The single-use component of claim 15, wherein said detection flow cell comprises a UV detection flow cell.