USE OF COHERENT RAMAN TECHNIQUES FOR MEDICAL DIAGNOSTIC AND THERAPEUTIC PURPOSES, AND CALIBRATION TECHNIQUES FOR SAME
First Claim
1. A method to measure the concentration of a target analyte in an animal subject using Raman spectroscopy comprising:
- measuring ex vivo a concentration of a target analyte in an animal subject;
illuminating a portion of said animal subject with light so as to cause radiation to scatter from a reference analyte and said target analyte in said sample;
detecting said scattered radiation from said reference analyte and from said target analyte;
measuring an electrical signal corresponding to an amount of detected radiation from said reference analyte;
measuring an electrical signal corresponding to an amount of detected radiation from said target analyte;
calculating an attenuation factor based on said signal from said reference analyte;
correcting the signal of said target analyte based on the attenuation factor; and
determining an absolute concentration of said target analyte in said animal subject from said corrected signal.
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Accused Products
Abstract
System and methods are provided to perform non-invasive, real-time, continuous molecular detection and quantification of molecular species in a sample or animal subject using Raman spectroscopy. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables a significantly more attractive course of therapy than existing protocols.
105 Citations
22 Claims
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1. A method to measure the concentration of a target analyte in an animal subject using Raman spectroscopy comprising:
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measuring ex vivo a concentration of a target analyte in an animal subject; illuminating a portion of said animal subject with light so as to cause radiation to scatter from a reference analyte and said target analyte in said sample; detecting said scattered radiation from said reference analyte and from said target analyte; measuring an electrical signal corresponding to an amount of detected radiation from said reference analyte; measuring an electrical signal corresponding to an amount of detected radiation from said target analyte; calculating an attenuation factor based on said signal from said reference analyte; correcting the signal of said target analyte based on the attenuation factor; and determining an absolute concentration of said target analyte in said animal subject from said corrected signal. - View Dependent Claims (2, 3, 4, 5, 6, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22)
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7. A system to measure the concentration of a target analyte using Raman spectroscopy comprising:
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a source of illumination that can cause radiation to scatter from a reference analyte and a target analyte in a sample; a detector to measure said scattered radiation from said reference analyte and from said target analyte; and a processor to calculate an attenuation factor based on said measure of scattered radiation from said reference analyte, to correct said measure of scattered radiation from said target analyte based on said attenuation factor; and
to determine an absolute concentration of said target analyte in said animal subject from said corrected measure of said target analyte. - View Dependent Claims (8, 9, 10, 11, 20)
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Specification