Biomarkers for Melanoma
First Claim
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1. A biomarker for melanoma status comprising one or more of Markers 1-104 or combinations thereof.
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Abstract
The present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates to methods of identifying biomarker for determining melanoma status in a subject.
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Citations
43 Claims
- 1. A biomarker for melanoma status comprising one or more of Markers 1-104 or combinations thereof.
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5. A method of qualifying melanoma status in a subject comprising:
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(a) measuring at least one biomarker in a sample from the subject, wherein the biomarker is selected from one or more of the biomarkers of Tables 1-3, and (b) correlating the measurement with melanoma status. - View Dependent Claims (6, 7, 8, 9)
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14-22. -22. (canceled)
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23. A method for identifying a candidate compound for treating melanoma comprising:
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a) contacting one or more of the biomarkers of Tables 1-3 with a test compound; and b) determining whether the test compound interacts with the biomarker, wherein a compound that interacts with the biomarker is identified as a candidate compound for treating melanoma.
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24. A method of treating melanoma comprising administering to a subject suffering from or at risk of developing melanoma a therapeutically effective amount of a compound capable of modulating the expression or activity of one or more of the biomarkers of Table 1.
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25. A method of treating a condition in a subject comprising administering to a subject a therapeutically effective amount of a compound which modulates the expression or activity of one or more of the biomarkers of Tables 1-3.
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26-28. -28. (canceled)
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29. A method for identifying a melanoma treatment, comprising:
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a) contacting a cell with a test compound, b) measuring at least one biomarker, wherein the biomarker is selected from one or more of the biomarkers of Tables 1-3, and c) correlating the measurement with a determination of efficacy. - View Dependent Claims (30)
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31. A method of determining the melanoma status of a subject, comprising:
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(a) obtaining a biomarker profile from a sample taken from the subject; and (b) comparing the subject'"'"'s biomarker profile to a reference biomarker profile obtained from a reference population, wherein the comparison is capable of classifying the subject as belonging to or not belonging to the reference population;
wherein the subject'"'"'s biomarker profile and the reference biomarker profile comprise one or more markers listed in Table 1.
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32-35. -35. (canceled)
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36. A method for the identification of a therapeutic target for melanoma comprising:
comparing an expression profile of a melanoma cell with an expression profile of one a reference cell, wherein the comparison is capable of classifying proteins or transcripts in the profile as being associated with invasion.
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37-40. -40. (canceled)
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41. A purified biomolecule selected from the biomarkers of Tables 1-3.
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42. A kit for aiding the diagnosis of melanoma, comprising:
an adsorbent, wherein the adsorbent retains one or more biomarkers selected from one or more of the markers of Table 1, and written instructions for use of the kit for detection of melanoma.
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43-45. -45. (canceled)
Specification