METHODS AND DEVICES FOR ADMINISTRATION OF SUBSTANCES INTO THE INTRADERMAL LAYER OF SKIN FOR SYSTEMIC ABSORPTION
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Abstract
Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.
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Citations
92 Claims
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1-66. -66. (canceled)
- 67. A method for administering a macromolecular pharmaceutical substance to a patient, the method comprising delivering a bolus of the substance intradermally via a needle inserted into the patient'"'"'s skin so that the needle penetrates the intradermal compartment wherein the needle'"'"'s outlet depth and exposed height of the outlet are located within the intradermal compartment, wherein the outlet has an exposed height of about 0 to 1 mm, so that the substance is delivered into the intradermal compartment and distributed systemically exhibiting a higher Cmax and a shorter Tmax of the substance, by comparison with subcutaneous administration of the substance at an identical dose and rate of delivery, wherein the macromolecular pharmaceutical substance is an interleukin, an interferon, a G-CSF, a GM-CSF, an EGF, a M-CSF, a TNF, or a TNF-antagonist.
Specification