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SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES

  • US 20080118934A1
  • Filed: 09/28/2007
  • Published: 05/22/2008
  • Est. Priority Date: 11/16/2006
  • Status: Active Grant
First Claim
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1. A method of probing multiple targets in a biological sample comprising:

  • (a) providing a biological sample containing multiple targets(b) binding at least one fluorescent probe to one or more target present in the sample;

    (c) binding at least one control probe to one or more target present in the sample;

    (d) observing a signal from the fluorescent probe bound in step (b) and a control signal from the control probe bound in step (c);

    (e) applying to the sample in step (d) a solution comprising an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe;

    (f) binding at least one fluorescent probe to one or more targets present in the sample of step (e); and

    (g) observing a signal from the fluorescent probe bound in step (f).

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