METHOD AND APPARATUS FOR AUTOMATED VASCULAR FUNCTION TESTING

• US 20080119741A1
• Filed: 11/22/2006
• Published: 05/22/2008
• Est. Priority Date: 11/22/2006
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Thomenius, Kai E., Dentinger, Aaron M., Friedman, Bruce A.
• Granted Patent: US 8,043,223 B2
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/4227 characterised by straps, belts, cuffs or braces

Abstract

A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.

Claims

1. A method of measuring a characteristic of an artery in a patient, the method comprising the steps of:

providing an ultrasound system having an ultrasound transducer;

providing a non-invasive blood pressure (NIBP) monitor having a selectively inflatable and deflatable pressure cuff, the NIBP monitor being in communication with the ultrasound system;

providing an optical plethysmographic sensor operable to detect each heartbeat cycle for the patient;

positioning the ultrasound transducer and the pressure cuff on the patient, the pressure cuff being located distal to the ultrasound transducer;

measuring a pulse wave transit time from the ultrasound transducer to the optical plethysmographic sensor;

automatically inflating the pressure cuff above a systolic pressure for the patient to occlude the artery for an occlusion period;

automatically deflating the pressure cuff after the occlusion period and communicating the deflation to the ultrasound system;

automatically detecting a parameter of an artery below the ultrasound transducer at a detection time within each heartbeat cycle after receiving notification of the pressure cuff deflation;

determining arterial compliance based upon the pulse wave transit time measured following the occlusion period; and

determining the endothelial dysfunction based upon the detected parameters of the artery following the occlusion period.

2. The method of claim 1 further comprising the steps of:

determining the parameter of the artery prior to inflation of the pressure cuff for the occlusion period; and

comparing the parameter of the artery after the occlusion period to the parameter of the artery before the occlusion period to determine the percent of dilation.

3. The method of claim 2 further comprising the steps of:

obtaining multiple parameter measurements for the artery following the deflation of the pressure cuff; and

automatically calculating the percentage of dilation based upon the maximum parameter detected.

4. The method of claim 3 wherein the parameter of the artery is a diameter of the artery.

5. The method of claim 3 wherein the parameter of the artery is the cross-sectional area of the artery.

6. The method of claim 1 further comprising the steps of:

determining the pulse wave transit time from the ultrasound transducer to the optical plethysmographic sensor prior to inflation of the pressure cuff for the occlusion period;

determining the pulse wave transit time from the ultrasound transducer to the optical plethysmographic sensor after the occlusion period; and

determining arterial compliance based upon the change in the pulse wave transit time determined prior to the occlusion period and after the occlusion period.

7. The method of claim 6 further comprising the steps of:

obtaining multiple measurements of the pulse wave transit time from the ultrasound transducer to the optical plethysmographic sensor following the deflation of the pressure cuff; and

determining the arterial compliance when the maximum diameter is detected.

8. The method of claim 1 wherein optical plethysmographic sensor is a pulse oximeter sensor of a pulse oximeter monitor.

9. A method of measuring a characteristic of an artery in a patient, the method comprising the steps of:

providing an ultrasound system having an ultrasound transducer;

providing a non-invasive blood pressure (NIBP) monitor having a selectively inflatable and deflatable pressure cuff, the NIBP monitor being in communication with the ultrasound system;

positioning the ultrasound transducer and the pressure cuff on the patient, the pressure cuff being located distal to the ultrasound transducer;

operating the ultrasound system to determine the pulse wave velocity beneath the ultrasound transducer;

automatically inflating the pressure cuff above a systolic pressure for the patient to occlude the artery for an occlusion period;

automatically deflating the pressure cuff after the occlusion period and electronically communicating the deflation to the ultrasound system;

automatically operating the ultrasound system to determine a parameter of the artery below the ultrasound transducer upon notification of the pressure cuff deflation; and

determining the endothelial dysfunction of the artery based upon the detected parameter and determining the arterial compliance based upon the detected pulse wave velocity.

10. The method of claim 9 wherein the ultrasound transducer is a sensor array having multiple sensors.

11. The method of claim 10 wherein the pulse wave velocity is determined between the multiple sensors of the ultrasound transducer.

12. The method of claim 9 wherein the parameter of the artery is a diameter of the artery, further comprising the steps of:

determining the diameter of the artery prior to inflation of the pressure cuff for the occlusion period; and

comparing the diameter of the artery after the occlusion period to the diameter of the artery before the occlusion period to determine the percent of dilation.

13. The method of claim 12 further comprising the steps of:

obtaining multiple diameter measurements for the artery following the deflation of the pressure cuff, and

automatically calculating the percentage of dilation based upon the maximum diameter detected.

14. The method of claim 9 wherein the characteristic of the artery is the blood flow through the artery.

15. The method of claim 9 further comprising the steps of:

determining the pulse wave velocity beneath the ultrasound transducer prior to the inflation of the pressure cuff for the occlusion period; and

determining arterial compliance based upon the change in the pulse wave velocity determined prior to the occlusion period and after the occlusion period.

16. The method of claim 15 further comprising the steps of:

obtaining multiple measurements of the pulse wave velocity from the ultrasound transducer following the deflation of the pressure cuff, and determining the arterial compliance when the maximum diameter is detected.

17. A system for the automatic determination of endothelial dysfunction and arterial health of a patient using flow mediated dilation, comprising:

a non-invasive blood pressure (NIBP) monitor having a pressure cuff positionable on the patient and selectively inflatable and deflatable by the NIBP monitor;

an optical plethysmographic monitor having an optical plethysmographic sensor positionable on the patient and operable to detect heartbeat cycles for the patient; and

an ultrasound system having an ultrasound transducer positionable on a limb of the patient and operable to determine at least a parameter of an artery below the ultrasound transducer over the heartbeat cycle, the ultrasound system being in communication with the NIBP monitor,

wherein the operation of the ultrasound monitor and the NIBP monitor are communicated to each other to inflate the pressure cuff above a systolic pressure for an occlusion period and to determine the parameter of the artery after deflation of the pressure cuff following the occlusion period,

wherein the ultrasound monitor and the optical plethysmographic monitor are operable to determine the pulse wave transit time from the ultrasound transducer to the pulse oximeter sensor.

18. The system of claim 17 wherein the plethysmographic monitor is a pulse oximeter monitor operable to detect the heartbeat cycles for the patient, wherein the ultrasound system determines the parameter of the artery at a detection time within each heartbeat cycle as determined by the pulse oximeter monitor.

19. The system of claim 17 wherein the ultrasound transducer is an array of sensor such that the sensor array is automatically operable to detect the artery beneath the ultrasound transducer.

20. The system of claim 19 wherein the ultrasound system is operable to determine the pulse wave velocity beneath the array of sensors.