SURGICAL PROSTHESIS HAVING BIODEGRADABLE AND NONBIODEGRADABLE REGIONS

• US 20080119877A1
• Filed: 12/05/2007
• Published: 05/22/2008
• Est. Priority Date: 08/12/2005
• Status: Abandoned Application

• Current Assignee: MAST Biosurgery AG
• Original Assignee: MAST Biosurgery AG
• Inventors: Mullins, Kenton R., Calhoun, Christopher J., Deusch, Kai
• Application Number:
  US11/951,081
• Publication Number:
  US 20080119877A1
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2250/0031 made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts

Abstract

A prosthesis for repairing a hernia includes an adhesion-resistant biodegradable region and an opposing tissue-ingrowth biodegradable region. When the prosthesis is implanted into the patient, the adhesion-resistant biodegradable region covers a fascial defect of the hernia, and the tissue-ingrowth biodegradable region is located above the adhesion-resistant biodegradable region while being exposed substantially only to the host'"'"'s subcutaneous tissue layer. This orientation allows the tissue-ingrowth biodegradable region to become firmly incorporated with the host'"'"'s body tissue. The adhesion-resistant biodegradable region faces the internal organs and decreases the incidence of adhesions and/or bowel obstruction.

Claims

1. A surgical implant for implantation in a host, comprising:

a substantially planar barrier membrane of resorbable polymer base material including (i) an adhesion-resistant region with a biodegradable component, and (ii) a tissue-ingrowth region that differs from the adhesion-resistant region in one or more of surface appearance and surface function, and

a non-biodegradable component contacting one or more of the tissue-ingrowth region and the adhesion-resistant region.

2. The surgical implant as set forth in claim 1, wherein:

the non-biodegradable component is included in a composition of at least one of the tissue-ingrowth region and the adhesion-resistant region, and

the non-biodegradable component affects one or more of a strength and a structural integrity of the at least one of the tissue-ingrowth region and the adhesion-resistant region.

3. The surgical implant as set forth in claim 1, wherein the non-biodegradable component (a) comprises a composition of the tissue-ingrowth region and (2) affects one or more of a strength and a structural integrity of the tissue-ingrowth region.

4. The surgical implant as set forth in claim 1, wherein the tissue-ingrowth region comprises a biodegradable component.

5. The surgical implant as set forth in claim 1, wherein the non-biodegradable component contacts the tissue-ingrowth region

6. The surgical implant as set forth in claim 1, wherein the non-biodegradable component is disposed within the tissue-ingrowth region

7. The surgical implant as set forth in claim 1, the non-biodegradable component forming the tissue-ingrowth region.

8. The surgical implant as set forth in claim 1, wherein the non-biodegradable component is disposed on a surface of the tissue-ingrowth region.

9. The surgical implant as set forth in claim 1, wherein:

the tissue-ingrowth region comprises a first composition;

the adhesion-resistant region comprises a second composition; and

the adhesion-resistant region comprises a resistance to adhesion that is greater than a resistance to adhesion that would be provided by the adhesion-resistance region if formed of the first composition.

10. The surgical implant as set forth in claim 1, wherein the non-biodegradable component contacts the adhesion-resistant region.

11. The surgical implant as set forth in claim 10, wherein the non-biodegradable component is disposed within the adhesion-resistant region.

12. The surgical implant as set forth in claim 1, wherein:

the adhesion-resistant region is resorbable; and

the tissue-ingrowth region is formed to have one or more of an open, non-smooth and featured surface.

13. The surgical implant as set forth in claim 1, wherein the tissue-ingrowth region is formed to have one or more of alveoli and pores.

14. The surgical implant as set forth in claim 1, wherein a thickness of the layer of resorbable polymer base material is greater than about 500 microns.

15. The surgical implant as set forth in claim 1, wherein the surgical implant comprises one or more of a poly-lactide polymer and a copolymer of at least two poly-lactides.

16. The device as set forth in claim 1, wherein the adhesion-resistant region is not fluid permeable.

17. The surgical implant as set forth in claim 1, wherein the tissue-ingrowth region is constructed with a surface appearance in the form of a surface topography, which differs from that of the anti-adhesion region and which facilitates one or more of strength, longevity and a substantial fibroblastic reaction in tissue of the host relative to the adhesion-resistant region.

18. The surgical implant as set forth in claim 1, wherein the tissue-ingrowth region is constructed with a surface function in the form of a surface composition, which differs from that of the anti-adhesion region and which facilitates one or more of strength, longevity and a substantial fibroblastic reaction in tissue of the host relative to the adhesion-resistant region.

19. The surgical implant as set forth in claim 1, wherein:

the tissue-ingrowth region forms a first side of the surgical implant; and

the adhesion-resistant region forms a second side of the surgical implant.

20. The surgical implant as set forth in claim 1, wherein the tissue-ingrowth region comprises a polymer or copolymer derived from one or more cyclic esters.

21. The surgical implant as set forth in claim 1, wherein the tissue-ingrowth region comprises one or more of

(a) a thermoplastic resin, (b) polymethacrylate,

(c) polymethylmethacrylate (PMMA), and (d) a combination thereof.

22. The surgical implant as set forth in claim 1, wherein the composition comprises strengthening and reinforcing fibers.

23. The surgical implant as set forth in claim 22, wherein the fibers comprise non-biodegradable polymers.

24. The surgical implant as set forth in claim 1, wherein heat bonding is used to join the tissue-ingrowth biodegradable region and the adhesion-resistant region.

25. The surgical implant as set forth in claim 1, the non-biodegradable component comprising a composition that affects a strength of the tissue-ingrowth region.