System and Method for Photoacoustic Guided Diffuse Optical Imaging
First Claim
1. A system for photoacoustic guided diffuse optical imaging of a sample, the system comprising:
- at least one light source configured to deliver light to the sample;
at least one ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light by the sample;
at least one optical detector for receiving optical signals generated due to light scattered by the sample; and
a control system in communication with the light source, the ultrasonic transducer, and the optical detector for reconstructing photoacoustic images of the sample from the received photoacoustic signals and reconstructing optical images of the sample from the received optical signals.
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Accused Products
Abstract
A system and method for photoacoustic guided diffuse optical imaging of a sample include at least one light source configured to deliver light to the sample, at least one ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light by the sample, and at least one optical detector for receiving optical signals generated due to light scattered by the sample. A control system is provided in communication with the at least one light source, the ultrasonic transducer, and the optical detector for reconstructing photoacoustic images of the sample from the received photoacoustic signals and reconstructing optical images of the sample from the received optical signals. The priori anatomical information and spatially distributed optical parameters of biological tissues from the photoacoustic images employed in diffuse optical imaging may improve the accuracy of measurements and the reconstruction speed.
172 Citations
29 Claims
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1. A system for photoacoustic guided diffuse optical imaging of a sample, the system comprising:
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at least one light source configured to deliver light to the sample; at least one ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light by the sample; at least one optical detector for receiving optical signals generated due to light scattered by the sample; and a control system in communication with the light source, the ultrasonic transducer, and the optical detector for reconstructing photoacoustic images of the sample from the received photoacoustic signals and reconstructing optical images of the sample from the received optical signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for photoacoustic guided diffuse optical imaging of a sample, the method comprising;
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providing at least one light source for delivering light to the sample; receiving photoacoustic signals generated due to optical absorption of the light by the sample with at least one ultrasonic transducer; receiving optical signals generated due to light scattered by the sample with at least one optical detector; and reconstructing photoacoustic images from the received photoacoustic signals and reconstructing optical images from the received optical signals. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A system for photoacoustic guided diffuse optical imaging, the system comprising:
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a first light source configured to deliver light pulses to a sample; an ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses from the first light source by the sample; a second light source configured to deliver light to the sample; an optical detector for receiving optical signals generated due to light scattered by the sample upon delivery of light by the second light source; and a control system in communication with the first light source and the second light source, in communication with the ultrasonic transducer for reconstructing photoacoustic images from the received photoacoustic signals, and in communication with the optical detector for reconstructing optical images from the received optical signals, wherein the control system is configured to combine the photoacoustic images and the optical images of the sample through image registration.
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Specification