Method of Providing Fast Relief to a User of a Nicotine Chewing Gum

• US 20080124283A1
• Filed: 11/30/2004
• Published: 05/29/2008
• Est. Priority Date: 11/30/2004
• Status: Active Grant

• Current Assignee: Fertin Pharma A/S
• Original Assignee: Fertin Pharma A/S
• Inventors: Andersen, Carsten
• Granted Patent: US 8,524,196 B2
• Time in Patent Office: Days
• US Class Current: 424/48
• CPC Class Codes: A61K 31/465 Nicotine; Derivatives thereof
• CPC Class Codes: A61K 9/0058 Chewing gums non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00
• CPC Class Codes: A61P 25/34 Tobacco-abuse

Abstract

The invention relates to a method of relieving nicotine craving comprising the steps of providing at least one chewing gum comprising tobacco alkaloid to a user, providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum, said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½ minute to about 2½ minutes from initiation of said chewing process.

Claims

1. Method of relieving nicotine craving comprising the steps of

providing at least one chewing gum comprising tobacco alkaloid to a user,

providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum,

said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½

minute to about 2½

minutes from initiation of said chewing process.

2. Method of relieving nicotine craving according to claim 1,

wherein said tobacco alkaloid comprises nicotine.

3. Method of relieving nicotine craving according to claim 1, wherein said transfer rate refer to a transfer of nicotine from the chewing gum to the exterior of the chewing gum.

4. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate is evaluated in sub periods of the period of about ½

minute to about 2½

minutes from initiation of said chewing process.

5. Method of relieving nicotine craving according to claim 1, wherein said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a further threshold transfer rate in the period of about 2½

minutes to about 10 minutes from initiation of said chewing process erably in the period of about.

6. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 2% of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period from ½

minutes to about 2½

minutes from initiation of said chewing process.

7. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 3% of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period from about ½

minute to about 2½

minutes from initiation of said chewing process.

8. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 5% of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period from about ½

minute to about 2½

minutes from initiation of said chewing process.

9. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 2% of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period of about 2½

minutes to about 5 minutes from initiation of said chewing process.

10. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 3% of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period of about 2½

minutes to about 5 minutes from initiation of said chewing process.

11. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 4% of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period of about 5 minutes to about 10 minutes from initiation of said chewing process.

12. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 2 to 10% of the tobacco alkaloid comprised in said chewing gum prior to chewing in the period of about 0 seconds to about 30 seconds from initiation of said chewing process.

13. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of less than 14% of the tobacco alkaloid comprised in said chewing gum prior to chewing in the period of about 0 seconds to about 2½

minutes from initiation of said chewing process.

14. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at most 18% of the tobacco alkaloid comprised in said chewing gum prior to chewing in the period of about 10 to about 30 minutes from initiation of said chewing process.

15. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 0.03 mg of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period from about ½

minute to about 2½

minutes from initiation of said chewing process.

16. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 0.05 mg of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period from about ½

minute to about 2½

minutes from initiation of said chewing process.

17. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 0.08 mg of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period from about ½

minute to about 2½

minutes from initiation of said chewing process.

18. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 0.03 mg of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period of about 2½

to about 5 minutes from initiation of said chewing process.

19. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 0.05 mg of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period of about 2½

minutes to about 5 minutes from initiation of said chewing process.

20. Method of relieving nicotine craving according to claim 1, wherein said threshold transfer rate results in a release of at least 0.08 mg of the tobacco alkaloid comprised in said chewing gum prior to chewing, every 30 seconds in the period of about 2½

minutes to about 5 minutes from initiation of said chewing process.

21. Method of relieving nicotine craving according to claim 1, wherein at least 0.5 mg of tobacco alkaloid is released within the initial 10 minutes of the chewing process.

22. Method of relieving nicotine craving according to claim 1, wherein different parts of the chewing gum is targeted tobacco alkaloid transfer at different times or in different periods of the chewing process.

23. Method of relieving nicotine craving according to claim 1, wherein said chewing gum comprises a coating and wherein said coating comprises tobacco alkaloid.

24. Method of relieving nicotine craving according to claim 1, wherein said chewing gum comprises substantially hydrophilic polymers.

25. Method of relieving nicotine craving according to claim 1, wherein the variation of transfer rate is minimized.

26. Method of relieving nicotine craving according to claim 1, wherein said tobacco alkaloid is comprised in an ion exchange resin.

27. Method of relieving nicotine craving according to claim 1, wherein said tobacco alkaloid comprises salts of nicotine.

28. Method of relieving nicotine craving according to claim 1, wherein said tobacco alkaloid comprises nicotine in its free from.

29. Method of relieving nicotine craving according to claim 1, wherein the tobacco alkaloid is buffered.

30. Method of relieving nicotine craving according to claim 1, wherein the chewing process is less than 30 minutes.

31. Method of relieving nicotine craving according to claim 1, wherein the chewing process is matching the smoking time of a cigarette.

32. Method of relieving nicotine craving according to claim 1, wherein said chewing gum comprises a polymer system in an amount of from about 2 to about 99% by weight, flavour in an amount of about 0.001 to about 30% by weight and sweeteners in an amount of about 2% to about 80% by weight.

33. Method of relieving nicotine craving according to claim 1, wherein said chewing gum comprises fillers in an amount of from about 0 to about 60% by weight, flavour in an amount of about 0.001 to about 30% by weight and sweeteners in an amount of about 2 to about 80% by weight.

34. Method of relieving nicotine craving according to claim 1, wherein said chewing gum comprises high intensity sweeteners in an amount of from about 0.001 to about 3% by weight and flavour in an amount of about 0.001 to about 30% by weight.

35. Method of relieving nicotine craving according to claim 32, wherein said polymer system comprises elastomers in an amount of about 0.1 to about 40% by weight of the chewing gum.

36. Method of relieving nicotine craving according to claim 32, wherein said polymer system comprises elastomer plasticizers in an amount of about 2 to about 60% by weight of the chewing gum.

37. Method of relieving nicotine craving according to claim 32, wherein said polymer system comprises wax in an amount of about 0 to about 30% by weight of the chewing gum.

38. Method of relieving nicotine craving according to claim 32, wherein said polymer system comprises softeners in an amount of about 2 to about 30% by weight of the chewing gum.

39. Method of relieving nicotine craving according to claim 32, wherein said polymer system comprises fillers in an amount of about 0 to about 50% by weight of the chewing gum.

40. Method of relieving nicotine craving according to claim 32, wherein said polymer system comprises antioxidants in an amount of about 0 to about 5% by weight of the chewing gum.

41. Method of relieving nicotine craving according to claim 1, wherein at least one piece of said chewing gum is chewed at a time.

42. Method of relieving nicotine craving according to claim 1, wherein at least two pieces of said chewing gum are chewed at a time.

43. Method of relieving nicotine craving according to claim 1, wherein at least one piece of said chewing gum is chewed a day.

44. Method of relieving nicotine craving according to claim 1, wherein at least one piece of said chewing gum is chewed when the person craves for nicotine.

45. Method of relieving nicotine craving according to claim 1, wherein at least one piece of said chewing is chewed when the person needs treatment including tobacco alkaloid or nicotine.