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Stable polypeptide formulations

  • US 20080124326A1
  • Filed: 10/05/2007
  • Published: 05/29/2008
  • Est. Priority Date: 10/20/2006
  • Status: Active Grant
First Claim
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1. A formulation comprising a buffer having a pH from about 4.0 to less than 6.0, a divalent cation between about 5-150 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic antibody having specific binding activity to human epidermal growth factor receptor (EGFR), wherein said therapeutic antibody retains at least about 80% stability for up to two months in solution.

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