Nanoparticle-based vaccine delivery system containing adjuvant

• US 20080124350A1
• Filed: 01/25/2008
• Published: 05/29/2008
• Est. Priority Date: 09/24/2002
• Status: Abandoned Application

• Current Assignee: University Of Kentucky Research Foundation (University of Kentucky)
• Original Assignee: University Of Kentucky Research Foundation (University of Kentucky)
• Inventors: Mumper, Russell, Cui, Zhengrong
• Application Number:
  US12/010,468
• Publication Number:
  US 20080124350A1
• Time in Patent Office: Days
• US Class Current: 424/184.1
• CPC Class Codes: A61K 2039/53 DNA (RNA) vaccination
• CPC Class Codes: A61K 2039/55544 Bacterial toxins
• CPC Class Codes: A61K 2039/55555 Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
• CPC Class Codes: A61K 2039/55572 Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61K 9/1272 with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids with cholesterol as the only non-phosphatidyl surfactant A61K9/127; lipids as modifying agent A61K47/543
• CPC Class Codes: A61K 9/5123 Organic compounds, e.g. fats, sugars

Abstract

A vaccine delivery system comprising adjuvant and nanoparticles comprising an immunogenic agent is provided. A method of immunizing an animal comprising administering a nanoparticle-based vaccine delivery system is also provided.

Claims

1. A vaccine delivery system comprising adjuvant and a plurality of nanoparticles comprising immunogenic antigen or nucleic acid encoding an immunogenic antigen.

2. The vaccine delivery system of claim 1 wherein the nanoparticles are cationic.

3. The vaccine delivery system of claim 1 wherein the nanoparticles are anionic.

4. The vaccine delivery system of claim 1 wherein the nanoparticles are neutral.

5. The vaccine delivery system of claim 1 wherein the nanoparticles comprise an anionic surfactant.

6. The vaccine delivery system of claim 1 wherein the nanoparticles comprise a cationic surfactant.

7. The vaccine delivery system of claim 1 wherein the nanoparticles comprise a neutral surfactant.

9. The vaccine delivery system of claim 1 wherein the immunogenic antigen is a polypeptide or peptide.

10. The vaccine of claim 1 wherein the adjuvant is selected from the group consisting of cholera toxin, lipid A, and monophosphoryl lipid A.

11. The vaccine of claim 1 wherein the adjuvant is cholera toxin.

12. The vaccine of claim 1 wherein the adjuvant is lipid A or monophosphoryl lipid A.

8. (canceled)

13. -26. (canceled)