Biocomposite for artificial tissue design

• US 20080124371A1
• Filed: 09/13/2007
• Published: 05/29/2008
• Est. Priority Date: 09/13/2006
• Status: Active Grant

• Current Assignee: University of South Florida (State University System of Florida)
• Original Assignee: University of South Florida (State University System of Florida)
• Inventors: Greenhalgh, Kerriann Robyn, Koob, Thomas J., Turos, Edward
• Granted Patent: US 8,093,027 B2
• Time in Patent Office: Days
• US Class Current: 424/422
• CPC Class Codes: A61L 2300/64 Animal cells
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

The present invention concerns a biocomposite useful in artificial tissue replacement, methods for its production, and methods of use. The biocomposite can be implanted into humans or animals as an artificial tissue for treatment of a tissue defect. The biocomposite can be formed or manipulated into a desired shape for implantation.

Claims

1. A synthetic biocomposite comprising a biotic material and an abiotic material.

2. The biocomposite of claim 1, wherein the biotic material is collagen and the abiotic material is a polymer.

3. The biocomposite of claim 1, wherein the biocomposite is a fiber comprising an intertwined polymer emulsion and fibrils.

4. The biocomposite of claim 3, wherein the fibrils are collagen fibrils.

5. The biocomposite of claim 1, wherein the abiotic material is a polymer emulsion.

6. The biocomposite of claim 1, wherein the abiotic material comprises a copolymer emulsion.

7. The biocomposite of claim 6, wherein the copolymer is ethyl acrylate-methyl methacrylate.

8. The biocomposite of claim 1, further comprising a biologically active agent.

9. The biocomposite of claim 8, wherein the biologically active agent is a cell.

10. A device comprising a surface with the synthetic biocomposite of claim 1 thereon.

11. The device of claim 10, wherein the device is a medical implant.

12. A method for producing a synthetic biocomposite, comprising polymerizing a biotic material and an abiotic material by emulsion polymerization, thereby forming the synthetic biocomposite.

13. The method of claim 12, wherein the biotic material is collagen and the abiotic material is a polymer.

14. The method of claim 12, wherein the biocomposite is a fiber comprising an intertwined polymer emulsion and fibrils.

15. The method of claim 14, wherein the fibrils are collagen fibrils.

16. The method of claim 12, wherein the abiotic material is a polymer emulsion.

17. The method of claim 12, wherein the abiotic material comprises a copolymer emulsion.

18. The method of claim 17, wherein the copolymer is ethyl acrylate-methyl methacrylate.

19. The method of claim 12, wherein the biocomposite further comprises a biologically active agent.

20. The method of claim 19, wherein the biologically active agent is a cell.

21. A method for treating a tissue defect, comprising defect, comprising applying a synthetic biocomposite at the sit of the defect, wherein the biocomposite comprises a biotic material and an abiotic material.