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Controlled release nanoparticulate compositions

  • US 20080124393A1
  • Filed: 10/31/2007
  • Published: 05/29/2008
  • Est. Priority Date: 10/01/1998
  • Status: Abandoned Application
First Claim
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1. A controlled release nanoparticulate clozapine composition comprising(a) clozapine particles having an effective average particle size of less than about 1000 nm;

  • (b) at least one surface stabilizer adsorbed on the surface of the clozapine particles, and(c) at least one pharmaceutically acceptable rate-controlling polymer, wherein the clozapine composition provides controlled release of the clozapine for a time period ranging from about 2 to about 24 hours or longer.

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