Infant Formula

• US 20080125346A1
• Filed: 08/22/2005
• Published: 05/29/2008
• Est. Priority Date: 08/20/2004
• Status: Abandoned Application

• Current Assignee: nv nutricia
• Original Assignee: N.V. Nutrica
• Inventors: Beermann, Christopher, Stahl, Bernd, Boehm, Gunther
• Application Number:
  US11/573,939
• Publication Number:
  US 20080125346A1
• Time in Patent Office: Days
• US Class Current: 514/2
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/22 Comminuted fibrous parts of plants, e.g. bagasse or pulp
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1862 Arachidonic acid
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/187 Eicosapentaenoic acid
• CPC Class Codes: A23V 2250/1872 Linoleic acid
• CPC Class Codes: A23V 2250/1874 Linolenic acid
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A23V 2250/5046 Fructan
• CPC Class Codes: A23V 2250/5072 Pectine, pectinate
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 31/7052 having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/02 : Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 37/02 : Immunomodulators
• CPC Class Codes: A61P 37/04 : Immunostimulants
• CPC Class Codes: A61P 37/08 : Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (Np_xN); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.

Claims

1-14. -14. (canceled)

15. A nutritional composition comprising

a. a protein,

b. a fat,

c. a carbohydrate;

d. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates; and

e. a non-proteinaceous, negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20,000 Dalton.

16. The nutritional composition according to claim 15, wherein the glycan or glycoconjugate component has a molecular weight between 1,000 and 10,000 Dalton.

17. The nutritional composition according to claim 15, comprising 5 to 15 energy % protein;

30 to 60 energy % fat; and

25 to 65 energy % carbohydrate.

18. The nutritional composition according to claim 15, comprising, per 100 gram dry weight of the composition, between 5 and 100 mg nucleotides;

between 5 and 100 mg nucleosides;

or both.

19. The nutritional composition according to claim 15, wherein the nucleotide component is ribose.

20. The nutritional composition according to claim 18, wherein the nucleotide component is ribose.

21. The nutritional composition according to claim 15 further comprising between 150 and 1000 mg calcium;

2 to 100 mg zinc;

or both.

22. The nutritional composition according to claim 15 wherein the negatively charged glycan or glycoconjugate component comprises acidic oligosaccharides, acid gangliosides, or both.

23. The nutritional composition according to claim 22, wherein the negatively charged glycan or glycoconjugate component is a polygalacturonic acid with a DP between 2 and 100.

24. The nutritional composition according to claim 23, wherein the polygalacturonic acid is pectin hydrolysate.

26. A method for providing nutrition to an infant, said method comprising administering to the infant a nutritional composition comprising

a. a protein,

b. a fat,

c. a carbohydrate;

d. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates; and

e. a non-proteinaceous, negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20,000 Dalton.

27. A method of treatment and/or prevention of an inflammatory disease, diarrhea, eczema and/or atopic dermatitis, comprising administering to the mammal a nutritional composition comprising

a. a protein,

b. a fat,

c. a carbohydrate;

d. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates; and

e. a non-proteinaceous, negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20,000 Dalton.

28. The method according to claim 27, wherein the inflammatory disease is allergy.

29. The method according to claim 28, wherein the mammal is a human.

30. The method according to claim 29, wherein the human is an infant.