Medical device package

• US 20080128296A1
• Filed: 12/12/2007
• Published: 06/05/2008
• Est. Priority Date: 01/26/2006
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Stopek, Joshua, Hotter, Joseph, Cohen, Matthew D.
• Granted Patent: US 9,364,215 B2
• Time in Patent Office: Days
• US Class Current: 206/63.3
• CPC Class Codes: A61B 17/06114 Packages or dispensers for needles or sutures packages for sharps A61B50/3001; for dental floss A61C15/043; packages for needles in general B65D85/24
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2050/0065 Peelable cover
• CPC Class Codes: A61B 2050/3005 containing a preservative liquid, e.g. an antiseptic liquid
• CPC Class Codes: A61B 2050/314 Flexible bags or pouches
• CPC Class Codes: A61B 2050/316 double- or multiple-walled
• CPC Class Codes: A61B 50/30 Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments for wound clamps A61B17/10; for ligaturing clips A61B17/122; packages or dispensers for surgical gloves or finger-stalls A61B42/40

Abstract

The present disclosure provides a package for a medical device having a surface prepared for receiving a target agent and a port for permitting the passage of the target agent between the surface of the medical device contained therein.

Claims

1. A sterile package for applying a predetermined amount of at least one target agent to a medical device comprising:

a container for receiving a medical device, wherein at least a portion of the medical device is prepared to receive at least one target agent; and

a port in communication with the container for allowing sterile passage of the at least one target agent to the prepared device.

2. The package of claim 1 wherein the medical device is selected from the group consisting of sutures, staples, clips, pledgets, buttresses, suture anchors, cables, wires, pacemakers, stents, catheters, inflatable devices, adhesives, sealants, meshes, sternum closures, pins, screws, tacks, rods, plates, adhesion barriers, bioelectronic devices, dental implants, surgical tools and combinations thereof.

3. The package of claim 1 wherein the medical device is a suture.

4. The package of claim 1 wherein at least a portion of the medical device is naturally prepared to receive a target agent.

5. The package of claim 1 wherein at least a portion of the medical device is prepared by a method selected from the group consisting of plasma-deposition, laser-based deposition, gamma-radiation induced polymerization, and chemical grafting using complimentary reactive functionality.

6. The package of claim 1, wherein at least a portion of the medical device is prepared by the addition of at least one coupling agent.

7. The package of claim 1 wherein the at least one target agent is selected from the group consisting of peptides, proteins, enzymes, antibodies, growth factors, cells, cell receptors, fibronectin, laminin, morphogenic factors, cell matrix proteins, genetic materials, viral vectors, nucleic acids, lymphokines, plasmids, drugs and combinations thereof.

8. The package of claim 1 wherein the at least one target agent is a drug.

9. The package of claim 8 wherein the drug is selected from the group consisting of antiseptics, anesthetics, muscle relaxants, antihistamines, decongestants, antimicrobial agents, anti-viral agents, anti-fungal agents, antimalarials, amebicides, antituberculosal agents, antiretroviral agents, leprostatics, antiprotazoals, antihelmitics, antibacterial agents, steroids, hematopoietic agents, antiplatelet agents, anticoagulants, coagulants, thrombolytic agents, hemorrheologic agents, hemostatics, plasma expanders, hormones, sex hormones, uterine-active agents, bisphosphonates, antidiabetic agents, glucose-elevating agents, growth hormones, thyroid hormones, inotropic agents, antiarrhythmic agents, calcium channel blockers, vasodilators, sympatholytics, antihyperlipidemic agents, vasopressors, angiotensin antagonists, sclerosing agents, anti-impotence agents, urinary alkanizers, urinary acidifiers, anticholinergics, diuretics, bronchodilators, surfactants, antidepressants, antipsychotics, antianxiety agents, sedatives, hypnotics, barbiturates, antiemetic agents, analgesics, stimulants, anticonvulsants, antiparkinson agents, proton pump inhibitors, H₂-antagonists, antispasmodics, laxatives, antidiarrheals, antiflatulents, digestive enzymes, gallstone solubilizing agents, antihypertensive agents, cholesterol-lowering agents, radiopaque agents, immune globulins, monoclonal antibodies, antibodies, antitoxins, antivenins, immunologic agents, anti-inflammatory agents, antineoplastic agents, alkylating agents, antimetabolites, antimitotic agents, radiopharmaceuticals, vitamins, herbs, trace elements, amino acids, enzymes, chelating agents, immunomodulatory agents, immunosuppressive agents and combinations thereof.

10. A method of applying a predetermined amount of a target agent to a medical device comprising:

providing a prepared medical device in a sterile package having a port for allowing sterile passage of at least one target agent to the device; and

introducing the target agent into the container through the port to interact with the prepared medical device.

11. The method of claim 10 wherein the medical device is selected from the group consisting of sutures, staples, clips, pledgets, buttresses, suture anchors, cables, wires, pacemakers, stents, catheters, inflatable devices, adhesives, sealants, meshes, sternum closures, pins, screws, tacks, rods, plates, adhesion barriers, bioelectronic devices, dental implants, surgical tools and combinations thereof.

12. The method of claim 10 wherein the medical device is a suture.

13. The method of claim 10 wherein at least a portion of the medical device is naturally prepared to receive a target agent.

14. The method of claim 10 wherein at least a portion of the medical device is prepared by a method selected from the group consisting of plasma-deposition, laser-based deposition, gamma-radiation induced polymerization, and chemical grafting using complimentary reactive functionality.

15. The method of claim 10, wherein at least a portion of the medical device is prepared by the addition of at least one coupling agent.

16. The method of claim 10 wherein the at least one target agent is selected from the group consisting of peptides, proteins, enzymes, antibodies, growth factors, cells, cell receptors, fibronectin, laminin, morphogenic factors, cell matrix proteins, genetic materials, viral vectors, nucleic acids, lymphokines, plasmids, drugs and combinations thereof.

17. The method of claim 10 wherein the at least one target agent is a drug.

18. The method of claim 17 wherein the drug is selected from the group consisting of antiseptics, anesthetics, muscle relaxants, antihistamines, decongestants, antimicrobial agents, anti-viral agents, anti-fungal agents, antimalarials, amebicides, antituberculosal agents, antiretroviral agents, leprostatics, antiprotazoals, antihelmitics, antibacterial agents, steroids, hematopoietic agents, antiplatelet agents, anticoagulants, coagulants, thrombolytic agents, hemorrheologic agents, hemostatics, plasma expanders, hormones, sex hormones, uterine-active agents, bisphosphonates, antidiabetic agents, glucose-elevating agents, growth hormones, thyroid hormones, inotropic agents, antiarrhythmic agents, calcium channel blockers, vasodilators, sympatholytics, antihyperlipidemic agents, vasopressors, angiotensin antagonists, sclerosing agents, anti-impotence agents, urinary alkanizers, urinary acidifiers, anticholinergics, diuretics, bronchodilators, surfactants, antidepressants, antipsychotics, antianxiety agents, sedatives, hypnotics, barbiturates, antiemetic agents, analgesics, stimulants, anticonvulsants, antiparkinson agents, proton pump inhibitors, H₂-antagonists, antispasmodics, laxatives, antidiarrheals, antiflatulents, digestive enzymes, gallstone solubilizing agents, antihypertensive agents, cholesterol-lowering agents, radiopaque agents, immune globulins, monoclonal antibodies, antibodies, antitoxins, antivenins, immunologic agents, anti-inflammatory agents, antineoplastic agents, alkylating agents, antimetabolites, antimitotic agents, radiopharmaceuticals, vitamins, herbs, trace elements, amino acids, enzymes, chelating agents, immunomodulatory agents, immunosuppressive agents and combinations thereof.