COMBINATION THERAPY FOR TREATMENT OF VIRAL INFECTIONS
First Claim
1. A method of treating a viral infection comprising(A) administering to a subject in need thereof at least one first antiviral agent for a first time period, wherein said at least one first antiviral agent does not inhibit host α
- -glucosidase; and
(B) after the first time period, sequentially or concurrently administering to the subject the at least one first antiviral agent and at least one second antiviral agent for a second time period, wherein the at least one second antiviral agent inhibits host α
-glucosidase.
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Accused Products
Abstract
One can treat a viral infection by first administering at least one first antiviral compound for a first time period and then, after the end of the first time period, concurrently or subsequently administering the at least one first antiviral compound and at least one second antiviral compound for a second period. In some cases, after the end of the second period, the same at least one second antiviral compound that was administered during the second time period may be administered for a third time period without concurrent or subsequent administration of the at least one first antiviral compound.
122 Citations
95 Claims
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1. A method of treating a viral infection comprising
(A) administering to a subject in need thereof at least one first antiviral agent for a first time period, wherein said at least one first antiviral agent does not inhibit host α - -glucosidase; and
(B) after the first time period, sequentially or concurrently administering to the subject the at least one first antiviral agent and at least one second antiviral agent for a second time period, wherein the at least one second antiviral agent inhibits host α
-glucosidase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
- -glucosidase; and
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28. A method of treating a viral infection comprising
(A) administering to a subject in need thereof at least one first antiviral agent for a first time period, wherein said at least first antiviral agent does not comprise an iminosugar; - and
(B) after the first time period, sequentially or concurrently administering to the subject the at least one first antiviral agent and at least one second antiviral agent for a second time period, wherein the at least one second antiviral agent comprises an iminosugar. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
- and
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53. A method of treating a viral infection comprising
(A) administering to a subject in need thereof at least one first antiviral agent for a first time period, wherein said at least first antiviral agent does not inhibit an ion channel activity; - and
(B) after the first time period, sequentially or concurrently administering to the subject the at least one first antiviral agent and at least one second antiviral agent for a second time period, wherein the second antiviral agent inhibits an ion channel activity. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
- and
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76. A method of treating a viral infection comprising
(A) administering to a subject in need thereof at least one first antiviral agent for a first time period, wherein said at least one first antiviral agent does not comprise a nitrogen-containing compound of formula VIII; - and
(B) after the first time period, sequentially or concurrently administering to the subject the at least one first antiviral agent and at least one second antiviral agent for a second time period, wherein the at least one second antiviral agent comprises a nitrogen-containing compound of formula VIII or a pharmaceutically acceptable salt thereof; - View Dependent Claims (77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95)
- and
Specification