Use of placental biomaterial for ocular surgery

• US 20080131522A1
• Filed: 10/03/2007
• Published: 06/05/2008
• Est. Priority Date: 10/03/2006
• Status: Abandoned Application

• Current Assignee: Celularity, Inc.
• Original Assignee: Celularity, Inc.
• Inventors: Ray, Cynthia, Liu, Qing
• Application Number:
  US11/906,961
• Publication Number:
  US 20080131522A1
• Time in Patent Office: Days
• US Class Current: 424/583
• CPC Class Codes: A61K 35/44 Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61P 27/00 Drugs for disorders of the senses
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: A61P 27/12 for cataracts

Abstract

The present application is directed to a method of performing ocular surgery using biomaterial from placenta and/or umbilical cord, wherein the biomaterial is contacted with a tissue of the eye, or tissue surrounding the eye, affected by the surgery. The biomaterial is also used in surgery performed to repair trauma to the eye, whether deliberately or accidentally caused. The eye surgery can be, e.g., glaucoma surgery, oculoplastic surgery, cataract surgery, vitreo-retinal surgery, refractive surgery, retinal surgery, eye muscle surgery, or the like.

Claims

1. A method of performing an ocular surgical procedure that involves a structure of an eye or tissue adjacent to an eye, comprising contacting said structure of the eye or tissue adjacent to the eye with umbilical cord membrane or umbilical cord biomaterial.

2. The method of claim 1, wherein said contacting comprises using said umbilical cord membrane as a patch over a discontinuity in said structure.

3. The method of claim 2, wherein said discontinuity is an incision made during said ocular surgical procedure.

4. The method of claim 3, wherein said ocular surgical procedure is creation of a scleral buckle.

14. The method of claim 1, wherein said ocular surgical procedure is a trabulectomy.

15. The method of claim 1, wherein said ocular surgical procedure is implantation of an orbital implant.

16. The method of claim 1, wherein said ocular surgical procedure is corneal surgery.

17. The method of claim 16, wherein said corneal surgery changes the shape of the cornea.

18. The method of claim 17, wherein said corneal surgery is photorefractive keratectomy (PRK), laser-assisted sub-epithelial keratectomy (LASEK), laser-assisted in situ keratomileusis (LASIK), automated lamellar keratoplasty (ALK), laser thermal keratoplasty (LTK), or conductive keratoplasty (CK).

21. The method of claim 1, wherein said ocular surgical procedure is retinal surgery.

22. The method of claim 1, wherein said ocular surgical procedure is an eye muscle surgery.

25. The method of claim 1, wherein said ocular surgical procedure is ciliarotomy, ciliectomy, ciliotomy, corectomedialysis, corectomy, corelysis, coremorphosis, coreplasty, coreoplasty, pupillomydriasis, cyclectomy, cyclectomy, iridectomesodialysis, iridodialysis, iridesis or iridocorneosclerectomy.

5. A kit comprising:

a. an isolated umbilical cord membrane or umbilical cord biomaterial; and

b. instructions for use of said isolated umbilical cord membrane or umbilical cord biomaterial in performing an ocular surgical procedure, wherein said ocular surgical procedure comprises contacting said structure of the eye or tissue adjacent to the eye with said umbilical cord membrane or umbilical cord biomaterial.

6. A method of performing an ocular surgical procedure that involves a structure of an eye or tissue adjacent to an eye, comprising contacting said structure of the eye or tissue adjacent to the eye with umbilical cord membrane or umbilical cord biomaterial, wherein said ocular surgical procedure is glaucoma surgery.

7. The method of claim 6, wherein said glaucoma surgery comprises implantation of a drainage implant or tube shunt.

8. The method of claim 7, wherein said umbilical cord membrane additionally contacts said drainage implant or said tube shunt.

9. The method of claim 8, wherein said umbilical cord membrane or umbilical cord membrane substantially prevents deterioration of said silicone tube for at least six months.

10. The method of claim 6, wherein said glaucoma surgery is trebeculoplasty, iridotomy, iridactomy, a filtering surgery, anterior sclerotomy, sclerostomy, penetrating trabeculotomy, non-penetrating trabeculotomy, trepanotrabeculectomy, goniotomy, cyclotomy, cycloanemization, cyclocryotherapy, cyclocryopexy, iridenclesis, iridocyclectomy, iridosclerotomy, corenclisis or goniocurretage.

11. A method of performing an ocular surgical procedure that involves a structure of an eye or tissue adjacent to an eye, comprising contacting said structure of the eye or tissue adjacent to the eye with umbilical cord membrane or umbilical cord biomaterial, wherein said ocular surgical procedure is cataract surgery.

12. The method of claim 11, wherein said cataract surgery comprises phacoemulsification of a cataract in said eye.

13. The method of claim 12 wherein said contacting comprises repair of a phacoemulsification burn.

19. A method of performing an ocular surgical procedure that involves a structure of an eye or tissue adjacent to an eye, comprising contacting said structure of the eye or tissue adjacent to the eye with umbilical cord membrane or umbilical cord biomaterial, wherein said ocular surgical procedure is vitreo-retinal surgery.

20. The method of claim 19, wherein said vitreo-retinal surgery is an anterior vitrectomy, pars plana vitrectomy, ignipuncture, macular hole repair, partial lamellar sclerouvectomy, or posterior sclerotomy.

23. A method of performing an ocular surgical procedure that involves a structure of an eye or tissue adjacent to an eye, comprising contacting said structure of the eye or tissue adjacent to the eye with umbilical cord membrane or umbilical cord biomaterial, wherein said ocular surgical procedure is oculoplastic surgery.

24. The method of claim 23, wherein said oculoplastic surgery is browplasty, eyelid reconstruction, blepharoplasty, ectropion repair, entropion repair, canthal resection, canthectomy, cantholysis, canthopexy, canthoplasty, canthorrhapy, canthotomy, canaliculodacryocystostomy, canaliculotomy, dacryoadenectomy, dacryocystectomy, dacryocystorhiostomy, dacryocystostomy, enucleation of the eye, evisceration or exenteration, or repair of an exposed orbital implant.