Composite implant and method for treating bone abnormalities

• US 20080132899A1
• Filed: 05/17/2005
• Published: 06/05/2008
• Est. Priority Date: 05/17/2004
• Status: Abandoned Application

• Current Assignee: Dfine Incorporated (Merit Medical Systems, Inc.)
• Original Assignee: Dfine Incorporated (Merit Medical Systems, Inc.)
• Inventors: Shadduck, John H., Truckai, Csaba
• Application Number:
  US11/130,837
• Publication Number:
  US 20080132899A1
• Time in Patent Office: Days
• US Class Current: 606/94
• CPC Class Codes: A61B 17/7095 the filler comprising unlinked macroscopic particles
• CPC Class Codes: A61B 17/8836 for heating, cooling or curing of bone cement or fluid fillers
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/04 Metals or alloys
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/425 of phosphorus containing material, e.g. apatite
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

This invention relates to implantable bone fill materials, systems and methods of treating bone abnormalities such as compression fractures of vertebrae, bone necrosis, bone tumors, cysts and the like. In an exemplary embodiment, the bone abnormality is accessed and a space is created by bone removal or compaction. An exemplary implant of the invention has a substantially fluid impermeable surface portion and an interior portion including an in-situ hardenable bone cement. The method of the invention includes applying energy to the fill material to accelerate polymerization and hardening of the material for supporting the bone.

Claims

1. A bone treatment method comprising the steps of:

(a) introducing into a bone a hardenable bone cement that includes an electrically conductive filler in a sufficient amount to allow ohmic heating of the bone cement; and

(b) delivering Rf energy to the bone cement wherein ohmic heating of the filler accelerates curing of the bone cement.

2. The bone treatment method of claim 1 wherein delivering Rf energy alters at least one the hardness, viscosity or elastic modulus of the bone cement.

3. The bone treatment method of claim 1 wherein step (a) introduces the bone cement within the interior of a deformable structure.

4. The bone treatment method of claim 3 wherein step (b) causes the deformable structure to become non-deformable.

5. A bone treatment method comprising the steps of:

(a) introducing a plurality of deformable elements into bone wherein each element includes a composition responsive to energy delivery from a remote energy source; and

(b) delivering energy to said composition wherein the response causes the elements to become non-deformable.

6. The method of claim 5 wherein delivering energy accelerates the polymerization of a bone cement.

7. The method of claim 5 wherein delivering energy sacrifices a barrier between first and second compositions to cause polymerization of said compositions.

8. The method of claim 5 wherein delivering energy sacrifices the surface of microcapsules carrying a polymerizing composition.

9. The method of claim 5 wherein delivering energy causes the elements to become non-deformable for reducing a supporting a fracture.

10. The method of claim 5 wherein delivering energy causes the elements to become non-deformable for supporting cortical bone.

11. The method of claim 5 wherein delivering energy includes delivering energy from at least one of a radiofrequency source, a light source, a microwave source and a magnetic energy source.

16. The implant system of claim 11 wherein the sacrificial element separates first and second components of an in-situ hardenable material.

12. An implant system for treating a bone abnormality comprising at least one implant having a first flexible state, the structure having a substantially impermeable surface portion and an interior portion that responds to energy delivery for altering the implant to a second inflexible state, and energy source for delivering energy to the at least one implant.

13. The implant system of claim 12 wherein said interior portion includes an in-situ hardenable material.

14. The implant system of claim 13 wherein the hardenable material is at least one of PMMA, monocalcium phosphate, tricalcium phosphate, calcium carbonate, calcium sulphate or hydroxyapatite.

15. The implant system of claim 12 wherein said interior portion includes a sacrificial element that can be sacrificed in response to energy delivery.

17. The implant system of claim 12 wherein hardenable material comprises at least one microencapsulated composition.

18. The implant system of claim 17 wherein each microcapsule includes a sacrificial surface that can be sacrificed in response to energy delivery.

19. The implant system of claim 12 wherein the energy source is at least one of a radiofrequency source, a laser source, a microwave source, a magnetic energy source.

20. A method of treating a bone a bone abnormality comprising:

(a) providing an implant body comprising a plurality concentric shells of a flexible, porous material;

(b) introducing the implant body into a bone in a collapsed condition; and

(c) injecting an in-situ hardenable bone fill material into an interior of the implant body thereby expanding the implant body wherein the shells substantially prevent extravasion of the fill material.

21. The method of claim 20 wherein step (a) provides shells of a perforated material.

22. The method of claim 20 wherein step (a) provides shells that are at least one of knit, woven or braided.

23. The method of claim 20 wherein step (a) provides shells that are of a polymer.