Coated implantable medical device
First Claim
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1. A medical device adapted for placement in a body vessel, the medical device comprising:
- a sleeve having a lumen surface and an outer surface; and
an anti-hypertensive bioactive agent adsorbed on or absorbed into the sleeve, the sleeve comprising a base material forming at least a portion of the outer surface.
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Abstract
A coated implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer posited on one surface of the structure; and at least one layer of a bioactive material posited on at least a portion of the coating layer. Preferably, the structure is a stent graft.
155 Citations
20 Claims
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1. A medical device adapted for placement in a body vessel, the medical device comprising:
- a sleeve having a lumen surface and an outer surface; and
an anti-hypertensive bioactive agent adsorbed on or absorbed into the sleeve, the sleeve comprising a base material forming at least a portion of the outer surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- a sleeve having a lumen surface and an outer surface; and
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12. An implantable medical device comprising:
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a sleeve material formed from a base material and having at least one surface; a coating layer having a thickness of at least about 50 Angstroms posited on the surface of the structure; and a bioactive material adsorbed into or absorbed into the coating layer. - View Dependent Claims (13, 14)
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15. A method for providing a bioactive material into a body lumen comprising the steps of:
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(a) providing a medical device cylindrical flexible sleeve; (b) applying to the cylindrical flexible sleeve a solution which includes a first volatile solvent, a first polymer dissolved in the solvent and a bioactive material dispersed in the first solvent; (c) evaporating the volatile solvent to form a coating layer comprising the bioactive material and the polymer on the cylindrical flexible sleeve; and (d) applying a porous layer comprising a second polymer on at least a portion of the coating layer by the steps of; (1) applying a solution which includes a second volatile solvent and the second polymer dissolved in the second solvent to the cylindrical sleeve; (2) evaporating the second solvent; and (3) repeating application and evaporating steps (1) and (2) to provide a coating layer of a thickness to provide for the controlled release of the bioactive material through the porous layer. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification